| acetylcholinesterase inhibitors
(AChE) |
|
|
|
|
|
| 1. galantamine |
AChE inhibitor |
halt the breakdown of acetylcholine
and stimulates nicotinic receptors which releases more acetylcholine |
mild-moderate |
1996 |
(45) |
| 2. rivastigmine |
AChE and Butyrylcholinesterase
inhibitor |
prevents
the breakdown of
butyrylcholine and acetylcholine |
mild-moderate |
1997 |
(46) |
| 3. donepezil |
AChE inhibitor |
averts the breakdown of
acetylcholine |
mild-moderate |
2001 |
(47) |
| antagonist
of NMDA receptor |
|
|
|
|
|
| 4. memantine |
NMDA antagonist |
obstructs the toxic effects
linked with excessive glutamate; controls glutamate activation |
moderate-severe |
2003 |
(48) |
| Aβ-targeting
monoclonal
antibodies |
|
|
|
|
|
| 5. aducanumab |
binding of aggregated Aβ
plaques |
eliminates
abnormal beta-amyloid
to help in reducing the no. of plaques |
mild |
2021 |
(37) |
