Table 2. Comparison of Different Anti-Oxidative Markers between Healthy Subjects and AD/MCI Patients.

antioxidative enzyme(s)/ marker(s)	comparison group	% change vs controls	total N (disease/ control)	brain region/ body tissue	ref
superoxide dismutase	AD	↓6.6%	36/36	red blood cells	(90)
	AD	↓88%, ↓71%	10/9	frontal cortex, temporal cortex	(91)
	AD	↓27%, ↓27%, ↓35%	12/12, 14/11, 8/5	cerebellum, frontal cortex, hippocampus	(92)
	MCI	↓20%	6/6	hippocampus	(87)
	MCI, AD	↓∼18%, ↓∼23%	15/15, 15/15	serum	(93)
	AD	significant decrease	n = 18	hippocampus	(94)
catalase	AD	↓34%	10/9	temporal cortex	(91)
	AD	significant decrease	n = 18, n = 22	hippocampus, frontal cortex	(94)
glutathione-S-transferase	MCI	↓30%	6/6	hippocampus	(87)
	AD	significant decrease	n = 18	hippocampus	(94)
glutathione peroxidase	MCI, AD	↓∼64%, ↓∼71%	15/15, 15/15	serum	(93)
	AD	significant decrease	n = 19	cerebellum	(94)
glutathione reductase	AD	significant decrease	n = 18, n = 19	hippocampus, cerebellum	(94)