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. 2022 Aug 5;15(8):dmm049514. doi: 10.1242/dmm.049514

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© 2022. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — SCA3 Purkinje cell dysfunction is heterogeneous. (A-F) The in vitro Purkinje cell recordings from 34-week-old animals demonstrated dependence on location of recording. When synaptic transmission was intact (A-C), Purkinje cell ISI CV (A) was increased, with a small increase in average (B) and predominant (C) firing rates only in SCA3 lobules VI-X. This held true when synaptic transmission was blocked (D-F). The increased ISI CV (D), increased average firing rate (E) and increased predominant firing rate is specific to SCA3 lobules VI-X. Synaptic transmission intact: wild-type I-V: N=10, n=43; wild-type VI-X: N=10, n=33. SCA3 I-V: N=5, n=14; SCA3 VI-X: N=13, n=54. Synaptic transmission blocked: wild-type I-V: N=7, n=29; wild-type VI-X: N=12, n=59. SCA3 I-V: N=11, n=43; SCA3 VI-X: N=14, n=59. *P<0.05, **P<0.01, ***P<0.001. One-way ANOVA with Bonferroni correction for multiple comparisons.