Table IV.
Histopathological analysis of psoriasis on the leg with vs without chronic venous insufficiency (CVI) and compared with stasis dermatitis
| Scorea,b | PLS n = 15 (100%) |
PLNOS n = 24 (100%) |
StD n = 15 (100%) |
PLS vs PLNOS p-value | PLS vs StD p-value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | |||
| Epidermal hyperplasia, quantitativeb | 3 (20) | 10 (67) | 2 (13) | 0 (0) | 5 (21) | 10 (42) | 9 (38) | 0 (0) | 2 (13) | 8 (53) | 5 (33) | 0 (0) | 0.29 | 0.25 |
| Suprapapillary thinning | 2 (13) | 2 (13) | 4 (27) | 7 (47) | 2 (8) | 5 (21) | 5 (21) | 12 (50) | 0 (0) | 0 (0) | 1 (7) | 14 (93) | 0.90 | 0.005 |
| Vessels with close contact to basal keratinocytes (“kissing vessels”) | 1 (7) | 8 (53) | 5 (33) | 1 (7) | 4 (17) | 10 (42) | 7 (29) | 5 (21) | 0 (0) | 0 (0) | 2 (13) | 13 (87) | 0.93 | < 0.001 |
| Neutrophils in cornified layer | 6 (40) | 4 (27) | 0 (0) | 5 (33) | 3 (13) | 10 (42) | 9 (38) | 2 (8) | 0 (0) | 1 (7) | 2 (13) | 12 (80) | 0.47 | 0.002 |
| Parakeratosis, staggered | 2 (13) | 9 (60) | 3 (20) | 1 (7) | 2 (8) | 14 (58) | 5 (21) | 3 (13) | 0 (0) | 0 (0) | 3 (20) | 12 (80) | 0.54 | < 0.001 |
| Parakeratosis, confluent | 3 (20) | 0 (0) | 6 (40) | 6 (40) | 1 (4) | 6 (25) | 5 (21) | 12 (50) | 0 (0) | 2 (13) | 3 (20) | 10 (67) | 0.67 | 0.15 |
| Spongiosis | 0 (0) | 4 (27) | 9 (60) | 2 (13) | 0 (0) | 7 (29) | 15 (63) | 2 (8) | 3 (20) | 7 (47) | 4 (27) | 1 (7) | 0.73 | 0.25 |
| Papillary fibrosis, vertical streaks | 0 (0) | 3 (20) | 6 (40) | 6 (40) | 0 (0) | 4 (17) | 6 (25) | 14 (58) | 0 (0) | 6 (40) | 5 (33) | 4 (27) | 0.34 | 0.26 |
| Fibrosis reticular dermis | 0 (0) | 0 (0) | 3 (20) | 11 (73) | 0 (0) | 0 (0) | 2 (8) | 22 (92) | 0 (0) | 6 (40) | 4 (27) | 5 (33) | 0.12 | 0.17 |
| Increased number of vessels papillary dermis | 1 (7) | 12 (80) | 2 (13) | 0 (0) | 1 (4) | 15 (63) | 7 (29) | 1 (4) | 3 (20) | 7 (47) | 5 (33) | 0 (0) | 0.17 | 0.70 |
| Increased number of vessels reticular dermis | 1 (7) | 4 (27) | 8 (53) | 2 (13) | 0 (0) | 9 (38) | 7 (29) | 8 (33) | 0 (0) | 7 (47) | 5 (33) | 3 (20) | 0.50 | 0.84 |
| Thick-walled vessels, papillary dermis | 0 (0) | 6 (40) | 9 (60) | 0 (0) | 0 (0) | 10 (42) | 14 (58) | 0 (0) | 1 (7) | 12 (80) | 2 (13) | 0 (0) | 0.92 | 0.007 |
| Papillary oedema | 0 (0) | 0 (0) | 5 (33) | 10 (66) | 0 (0) | 3 (13) | 5 (21) | 16 (67) | 3 (20) | 1 (7) | 8 (53) | 3 (20) | 0.79 | 0.005 |
a
Semi-quantitative scores: 1=strongly present, 2=present, 3=weakly present, 4=not present.
b
Quantitative score for hyperplasia: >0.4 mm=strongly present, 0.4-0.2 mm=present, <0.2=weakly present.
Bold indicates statistically significant p < 0.05. PLNOS: psoriasis on the leg not otherwise specified; StD: stasis dermatitis; PLS: psoriasis on the leg with CVI.