Table 5.
Healthcare resource utilization for one year after index date for patients in the incident study cohort (patients with the start of any major depressive disorder episode within the study period, 1/1/2016–31/5/2018) by treatment resistant depression, n = 2553
| Patients without TRD (N = 1929, 75.6%) | Patients with TRD (N = 624, 24.4%) | Total (n = 2553) | P-value | ||
|---|---|---|---|---|---|
| Visits – Primary care physician | ≥ 1, n (%) | 1858 (96.3%) | 613 (98.2%) | 2471 (96.8%) | 0.018 |
| Quantity, median (IQR) | 10 (6, 16) | 14 (9, 21) | 11 (7, 17) | < 0.001 | |
| Visits—Psychiatrist | ≥ 1, n (%) | 1745 (90.5%) | 600 (96.2%) | 2345 (91.9%) | < 0.001 |
| Quantity, median (IQR) | 3 (2, 5) | 6 (3, 9) | 4 (2, 6) | < 0.001 | |
| Emergency room visits | ≥ 1, n (%) | 415 (21.5%) | 163 (26.1%) | 578 (22.6%) | 0.017 |
| Quantity, median (IQR) | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | 0.005 | |
| Hospitalizations | ≥ 1, n (%) | 262 (13.6%) | 138 (22.1%) | 400 (15.7%) | < 0.001 |
| Number of separate hospitalizations, median (IQR) | 1 (1, 2) | 1 (1, 2) | 1 (1, 2) | 0.267 | |
| Number of nights, median (IQR) | 4 (2, 13.5) | 6 (2, 39) | 5 (2, 20) | 0.031 | |
| Psychiatric Hospitalizations | ≥ 1, n (%) | 66 (3.4%) | 57 (9.1%) | 123 (4.8%) | < 0.001 |
| Number of separate hospitalizations, median (IQR) | 1 (1, 1) | 1 (1, 2) | 1 (1, 2) | 0.031 | |
| Number of nights, median (IQR) | 20 (6, 42) | 40 (10, 67) | 27.5 (8, 61) | 0.279 | |
| Electroconvulsive therapy | ≥ 1, n (%) a | 14 (0.7%) | 18 (2.9%) | 32 (1.3%) | < 0.001 |
| Time to ECT treatment, for those that initiated treatment after index date, median (IQR) | 5.39 (3.12, 18.63) | 10.5 (4.28, 16.95) | 9.99 (3.53, 16.25) | 0.733 | |
aexcluding those with ECT before index date
TRD treatment resistant depression, ECT electroconvulsive therapy