Table 1.
Tumors selected for DNA sequencing strategies, based on clinical responsea
WESb (n= 51) | Docetaxel responder | Docetaxel non-responder | Docetaxel not evaluable | |||
CR | PR | SD | PD | |||
Epirubicin responder | CR | 2 (1) | ||||
PR | 2 (1) | 6 (3) | 13 (4) | 2 (0) | ||
Epirubicin non-responder | SD | 8 (1) | 15 (0) | |||
PD | 2 (1) | 1 (0) | ||||
Ampliconc (n= 45) | Docetaxel responder | Docetaxel non-responder | Docetaxel not evaluable | |||
CR | PR | SD | PD | |||
Epirubicin responder | CR | 1 (0) | ||||
PR | 4 (0) | 2 (0) | 9 (1) | 2 (1) | ||
Epirubicin non-responder | SD | 1 (0) | 3 (1) | 21 (0) | 1 (0) | 1 (0) |
PD |
Numbers in paratheses indicate patients with pCR at surgery
aTumors selected as response outliers (response per RECIST) and with tumor tissue available for DNA extraction (n = 96/109)
bWES whole exome sequencing
cAmplicon: amplicon-based sequencing of 6-gene panel