Table 1.
List of biomaterials used for the treatment of ovarian aging
| Categories | Author | Year | Materials | Model | Major finding | |
|---|---|---|---|---|---|---|
| Extracellular vesicles | Bo Sun [145] | 2019 | BMSC-derived exosomes | Cisplatin-induced POF mouse model | Inhibited the apoptosis of granulosa cell. | |
| Meiling Yang [147] | 2020 | BMSC-derived exosomes | Cyclophosphamide-induced POF mouse model | Prevented follicular atresia and GCs apoptosis. | ||
| Zhongkang Li [148] | 2021 | hUCMSC-derived exosomes | Cyclophosphamide-induced POI mouse model | Reduced cell apoptosis and enhanced proliferation. | ||
| Conghui Liu [149] | 2020 | hUCMSC-derived exosomes | Busulfan and cyclophosphamide-induced POI mouse model | Improved the fertility of POI mice without adverse effects on the cognitive behavior of their offspring. | ||
| Ziling Yang [150] | 2019 | hUCMSC-derived exosomes | Busulfan and cyclophosphamide-induced POI mouse model | Restored ovarian function by promoting angiogenesis. | ||
| Chenyue Ding [151] | 2020 | hUCMSC-derived exosomes | Cyclophosphamide-induced POI mouse model | Reduced ROS levels in the damaged ovary and suppressed SIRT7 expression. | ||
| Jin Zhang [152] | 2020 | hUCMSC-derived exosomes | Cisplatin-damaged granulosa cells | Promoted resistance to cisplatin-induced granulosa cells apoptosis and restored synthesis and secretion of steroid hormone in granulosa cells. | ||
| Liping Sun [153] | 2017 | hUCMSC-derived exosomes | Cisplatin-damaged granulosa cells | Ameliorated cisplatin-induced granulosa cells stress and apoptosis in vitro. | ||
| Boxian Huang [155] | 2018 | hADMSC-derived exosomes | Cyclophosphamide-induced POI mouse model | Inhibited expression of the apoptosis genes in human granulosa cells and improved ovarian function. | ||
| Chenyue Ding [157] | 2020 | hAMSCs-derived exosomes | Cyclophosphamide-induced POI mouse model | Improved proliferation, inhibited apoptosis, reduced ROS level and decreased the expression of SIRT4 and relative genes in POI hGCs and ovaries. | ||
| Qiuwan Zhang [14] | 2019 | hAECs-derived exosomes | Busulfan and cyclophosphamide-induced POI mouse model | Increased follicles,inhibited GCs apoptosis and protected the ovarian vasculature from damage in POF mice. | ||
| Guan-Yu Xiao [163] | 2016 | AFMSCs-derived exosome | Busulfan and cyclophosphamide-induced POF mouse model | Inhibited apoptosis in damaged GCs and prevented ovarian follicles from atresia. | ||
| Eman Thabet [164] | 2020 | AFMSCs-derived extracellular vesicles | Cyclophosphamide-induced premature ovarian dysfunction rats model | Restored total follicular counts, AMH levels,regular estrous cycles and fruitful conception. | ||
| Siwen Zhang [166] | 2021 | MenSCs-derived exosomes | 4-Vinylcyclohexene diepoxide-induced POI mouse model | Promoted follicular development, restored fertility and improved live birth. | ||
| Chenfeng Yuan [172] | 2021 | Follicular fluid exosomes | Porcine granulosa cells | Increased the proliferation and progesterone synthesis of porcine ovarian granulosa cells. | ||
| Samuel Gebremedhn [173] | 2020 | Follicular fluid exosomes | Bovine granulosa cells | Protected against heat stress by reducing the amount of ROS accumulation. | ||
| Thais A Rodrigues [174] | 2019 | Follicular fluid exosomes | Cultured cumulus—oocyte complex | Increased the resistance of the oocyte to heat shock and improved the cleavage and blastocyst rates. | ||
| Extracellular matrix | Monica M Laronda [180] | 2015 | SDS | Ovariectomized mice | It could significantly change ECM, and had a strong destructive effect on the ultrastructure of natural tissues. | |
| S E Pors [186] | 2019 | 0.1% SDS and DNA enzymes | Immunodeficient mice | Adequately decellularized both human ovarian medullary and cortical tissue by eliminating all cells and leaving the ECM intact. | ||
| Wen-Yue Liu [187] | 2017 | Triton X-100 solution and DNA enzyme | Rats | Had no cytotoxicity to rat ovarian cells in vitro and only caused minimal immunogenic response in vivo. | ||
| Maryam Nezhad Sistani [188] | 2021 | 1%Triton X-100 and 0.5%SDS | The endometrial mesenchymal cells | It could effectively decellularize human ovarian tissue and highly preserve ECM content and non-cytotoxic properties. | ||
| Farideh Eivazkhani [184] | 2019 | NaOH used as a satisfactory decellularization agent | Ovariectomized mice | It supported follicular reconstruction better than SDS. | ||
| Ashraf Hassanpour [179] | 2018 | SLES as an ionic detergent | Ovariectomized rats | Preserved the structure and composition of ovarian ECM, and promoted in vitro and in vivo biocompatibility and neovascularization of biological ovarian scaffides. | ||
| Hossein Nikniaz [190] | 2021 | Human and bovine acellular ovarian scaffold | Mouse preantral follicles | Sodium alginate containing acellular ovarian scaffold could maintain follicular viability in vitro. | ||
| Sanaz Alaee[191] | 2021 | Decellularized rat ovarian scaffold | Preantral follicles from prepubertal mice | The preantral follicles transformed into antral follicles, and produced mature meiosis oocytes. | ||
| Wen-Yue Liu[187] | 2017 | Porcine acellular scaffold | Rat ovarian tissue | Supported the adhesion, migration, and proliferation of immature female rat granulose cells and showed estradiol secretion. | ||
| S E Pors [186] | 2019 | Acellular human ovarian tissue | Human preantral follicles | Supported the survival of human follicles. | ||
| Eun Jung Kim [192] | 2020 | ECM-derived hydrogel | Mouse ovarian follicles | Supported follicular morphology and growth, and promoted oocyte maturation. | ||
|
Ashraf Hassanpour [179] |
2018 | Acellular scaffold of human ovarian tissue | Ovariectomized mice | Increased vaginal opening and estrogen levels after implantation and confirmed the onset of puberty. | ||
| Monica M Laronda [180] | 2015 | Acellular bovine ovarian scaffold | Ovariectomized mice | Supported the growth of isolated mouse follicles, and produced estrogen and reconstructed menstrual cycles. | ||
| Georgia Pennarossa [193] | 2021 | Porcine ovarian 3D biological scaffold | Female germ line stem cells | Represented a powerful tool for in vitro recreation of a bioengineered ovary that might constitute a promising solution for hormone and fertility function restoring. | ||
| Kutluk Oktay[194] | 2016 | Human extracellular tissue matrix scaffold | Human | Pregnancies had been reported following minimally invasive transplantation of previously cryopreserved ovarian tissue. | ||
| Collagen | Sunyoung Joo[198] | 2016 | Collagen-rich, biomimetic 3D shells | Rodent ovarian follicles | Collagen hydrogel properties were important for follicular phenotype and function maintenance. | |
| C Torrance [199] | 1989 | A collagen gel matrix | Mouse preantral follicles | Allowed mouse follicles to separate and grow in vitro for at least 2 weeks. | ||
| G Taru Sharma [200] | 2009 | A 3D collagen gel culture system | Buffalo preantral follicles | Maintained follicle viability and growth by providing surface interaction and increasing attachment of follicles. | ||
| Kossowska-Tomaszczuk [205] | 2010 | A three-dimensional culture system containing type I collagen | Immunodeficient mice | Allowed granulosa cell subpopulations isolated from mature follicles to survive and grow, and supported their proliferation into steroid-producing spherical structures. | ||
| Saori Itami [206] | 2011 | A three-dimensional collagen gel | Mouse preantral follicles | The follicle could maintain its three-dimensional shape, and increase its size in response to FSH stimulation. | ||
| R Abir [201] | 1999 | collagen gel | Monolayer follicles from human ovarian tissue | Reported an increase in the GC layer and oocyte diameter of human follicles. | ||
| Catherine M H Combelles [202] | 2005 | 3D collagen gel matrix | Cumulus cells | Established for the first time an effective in vitro fertilization combined culture system of human denuded oocytes and cumulus cells. | ||
| L Vanhoutte [213] | 2009 | Collagen (type I) gel | Dermished foamed oocytes | The fertilization rate of 3D pre-cultured oocytes was significantly higher than that of conventional IVM oocytes. | ||
| Yanjun Yang [214] | 2019 | The collagen scaffold loaded with hUCMSCs | Cyclophosphamide-induced POF mouse model | Increased the levels of E2 and AMH, ovarian volume and the number of antral follicles. | ||
| Jing Su [154] | 2016 | The collagen scaffold with ADSCs | Tripterygium Glycosides -induced POF rat model | Increased long-term retention of ADSCs in the ovary and contributed to the restoration of ovarian function. | ||
| Lijun Ding [215] | 2018 | The collagen scaffold with umbilical cord mesenchymal stem cells | Infertile POF patients | Saved overall ovarian function and leaded to a successful clinical pregnancy. | ||
| Hyaluronic acid | Nina Desai [219] | 2012 | A tyramine-based HA hydrogel | Mouse preantral follicles | Promoted the secretion of estradiol and increased the survival rate, GV rupture rate and MII formation rate of cultured follicles. | |
| I R Brito [220] | 2016 | A novel hyaluronic acid hydrogel based on tyramine-substituted sodium hyaluronate dihydroxyphenyl bond | Goat preantral follicles | Failed to maintain survival and improve antral formation. | ||
| Parisa Jamalzaei [222] | 2020 | A HAA composed of HA and ALG | Mouse preantral follicles | Promoted the development of preantral follicles and oocyte maturation in mice and enhanced estrogen secretion. | ||
| L M G Paim [224] | 2015 | A vitrification solution with 1% hyaluronic acid | The cumulus oocyte complex | Improved the meiotic recovery rate and nuclear maturation rate of norvegicus oocytes. | ||
| Somayeh Tavana [225] | 2016 | The HABH | Ovariectomized rats | Prevented or reduced early ischemia-induced follicular loss, promoted follicular survival and angiogenesis. | ||
| Maryam Akhavan Taheri [226] | 2016 | HA hydrogel | Ovariectomized rats | Had no negative effect on estrus cycle recovery and ovarian preservation,and improved the outcome of autologous transplantation. | ||
| Or Friedman [227] | 2012 | HA—rich biogel | Immunodeficient mice | Improved ovarian graft survival. | ||
| Wenlin Jiao [228] | 2022 | A combination of UCMSCs and HA gel | 4-Vinylcyclohexene diepoxide -induced POI mouse model | Improved follicular survival. | ||
| Eun-Young Shin [229] | 2021 | HA gel scaffolder | Cisplatin-induced POI mouse model | Restored the ovarian structure and function and improved the quality of oocyte and embryo as well as the regularity of estrus cycle. | ||
| Guangfeng Zhao [230] | 2015 | HA | Immunosuppressive drug-induced POI-like rat model | Prevented chemotherapy-induced ovarian damage. | ||
| Fibrin | Seyedeh Zeynab Sadr [235] | 2018 | Fibrinalginate scaffold | Mouse preluminal follicles | Improved follicular development and survival, and produced mature oocytes. | |
| Shi Ying Jin [240] | 2010 | A fibrinalginate hydrogel matrix | Mouse secondary follicles | Supported the growth of secondary follicles to the antral follicles stage and produced mature oocytes. | ||
| Ariella Shikanov [239, 241] |
2011 2009 |
The FA-IPN | Mouse secondary follicles | Contributed to increased meiosis maturation rates of oocytes. | ||
| I R Brito [220] | 2016 | Fibrinalginate | Goat preluminal follicles | Restored oocyte meiosis and promoted oocyte maturation to produce parthenotes. | ||
| J Xu [242] | 2011 | A fibrin alginate matrix | Rhesus monkey secondary follicles | Supported the growth of secondary follicles to antral follicles stage, and promoted the maturation of oocytes to MII stage. | ||
| J Xu [243] | 2013 | Fibrinin-sodium alginate 3D capsule | Primate rhesus monkey primary follicles | Primate oocytes derived from primary follicles developed in vitro had the ability to restart meiosis for fertilization. | ||
| Alireza Rajabzadeh [245] | 2020 | A fibrin hydrogel scaffold supplemented with platelet lysates | Mouse preantral follicles | Improved the local vascularization of follicles, and the survival rate of follicles, and promoted the growth of follicles to the stage of antral follicles. | ||
| Valérie Luyckx [246] | 2014 | A fibrin matrix containing low concentrations of fibrinogen and thrombin | Mouse preantral follicles and ovarian cells | All follicles were found to be alive or only slightly damaged and to grow to the antral follicular stage. | ||
| M C Chiti [247] | 2016 | Fibrinogen and thrombin (F12.5/T1) substrates | SCID mice | Isolated secondary follicles survived and grew to the antral follicle stage. | ||
| Rachel M Smith [248] | 2014 | Fibrin hydrogel | Infertile mouse model | Restored ovarian endocrine function. | ||
| Fernanda Paulini [249] | 2016 | A fibrin matrix containing fibrinogen and thrombin | Nude mice | Isolated human follicles were viable after encapsulation in fibrin clots and short-term xenotransplantation. | ||
| Ariella Shikanov [244] | 2011 | Heparin modified fibrin | Infertile mouse model | Reduced ischemia and improved vascular remodeling. | ||
| Jiang-Man Gao[250] | 2013 | Fibrin hydrogels mixed | Adult female mice | Increased follicular survival and improved revascularization. | ||
| Chungmo Yang [251] | 2021 | Fibrin hydrogel containing NO-NPs | Ovariectomized mice | Improved the total number and quality of follicles, induced angiogenesis, and prevented ischemic injury. | ||
| Elham Shojafar [252] | 2019 | Platelette-rich fibrin biofolders | Ovariectomized mice | Reduced oxidative stress, promoted revascularization, and protected follicular cisterns from ischemia–reperfusion injury. | ||
| Maria Costanza Chiti [237] | 2018 | A novel fibrin matrix | Human ovarian follicles | Fibrin matrix composed of F50/T50 most closely resembled human ovarian cortex. | ||
| Valérie Luyckx [238] | 2013 | A artificial ovary composed of fibrinogen and thrombin | Human ovarian cells | Enabled the survival and proliferation of isolated human ovarian stromal cells. | ||
| Alginate | Hudson H V Correia [259] | 2020 | A sodium alginate 3D culture system | Goat primordia follicles | Showed appropriate survival rate, high follicular activation rate and continued to grow throughout culture. | |
| Samaneh Sadeghnia [261] | 2016 | A sodium alginate three-dimensional culture system | Sheep primordial/primary follicles | 2% sodium alginate supported follicle growth better than 1% sodium alginate. | ||
| Min Xu [262] | 2006 | An alginate hydrogel matrix | Pseudopregnant female mice | Produced healthy and fertile progenies. | ||
| Jing Xu [263] | 2010 | Alginate | Rhesus monkey secondary follicles | Grew to the antral follicle stage, produced steroids and growth factors, and produced healthy oocytes within 40 days. | ||
| Min Xu [264] | 2009 | Alginate | Rhesus monkey secondary follicles | The follicles survived and continued to grow. | ||
| Alon Kedem [266] | 2011 | Macropores sodium alginate scaffold | Human ovarian cortex slices | There was an increase in developing follicle culture and a decrease in atretic follicles. | ||
| Monica M Laronda [267] | 2014 | Sodium alginate hydrogel | Human ovarian cortex containing primordial follicles | The ovarian cortex grew, survived, and supported follicular development for up to 6 weeks. | ||
| Christiani A Amorim [268] | 2009 | alginate matrix | Small human preantral follicles | Survived in vitro culture in alginate matrix for 7 days. | ||
| Antonella Mastrorocco[269] | 2021 | Alginate microspheres | Lamb cumulus oocyte complexes | Increased the nuclear maturation rate of preadolescent oocytes and reduced the incidence of chromosome abnormality. | ||
| Parisa Jamalzaei [270] | 2020 | ALG hydrogel | Mouse preantral follicles | Survival rate of 0.5%ALG cultured follicles was significantly higher than 0.75% and 1%ALG cultured follicles. | ||
| Cyrus Jalili [271] | 2020 | Sodium alginate | Mouse preantral follicles | 0.5% alginate was the most favorable concentration. | ||
| Erin R West[258] | 2007 | Alginate gel | Mouse secondary oocytes | Reducing alginate matrix hardness could maintain intercellular tension homeostasis, promote cell process, create local paracrine environment and improve oocyte quality. | ||
| Julie Vanacker [273] | 2014 | Alginate saline gel | Immunodeficient mice | Promoted follicular development and vascularization. | ||
| Sivanandane Sittadjody [274] | 2017 | Sr++ cross-linked alginate | Ovariectorized rats | Achieved stable hormone secretion and improved the adverse effects of hormone deficiency. | ||
| Shani Felder [275] | 2019 | Macrofenate scaffold | Ovariectorized mice | Showed high serum hormone levels and the appearance of the vaginal area. | ||
| Sythetic biomaterials | Jiwon Kim [276] | 2016 | A synthetic hydrogel, PEG-VS | Ovariectorized mice | It was found to wrap immature follicles successfully functioned as an artificial ovarian tissue in vivo for 60 days. | |
| Uziel Mendez [277] | 2018 | A three-dimensional PEG-based culture system | Mice follicles | Improved the survival and maturation rates of small follicles. | ||
| Zhonghua Shi [278] | 2021 | A supramolecular hydrogel | Aged mice | Delayed ovarian aging in aged mice,stimulated ovaries to secrete estrogen and progesterone, and developed more antral follicles for reproduction. | ||
| Anu David [279] | 2017 | A TheraCyte device | Ovariectomized mice | Restored follicular development and ovarian endocrine function and reduced FSH levels. |