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. 2022 Aug 11;365:110097. doi: 10.1016/j.cbi.2022.110097

Table 1.

In vivo concentration ranges of the study compounds.

Name of compound Molecular weight Concentration use in this study In vivo Cmax Dose Subjects N Reference
g/mol μg/mL μM μg/mL μM
Aripiprazole 448.39 10.00 22.30 0.14 0.31 P.O. 10 mg/day tablets Healthy subjects 24 [17]
Ziprasidone 412.94 10.00 24.22 0.09 0.22 P.O. 40 mg tablets Healthy subjects 10 [18]
CBN 310.43 10.00 32.21 0.01 0.02 Case report [19]
THC 314.45 10.00 31.80 1.10 3.50 Case report [19]
CBD 314.47 10.00 31.80 1.39 4.40 P.O. 1500 mg CBD twice daily Healthy subjects 9 [20]
Dexamethasone 392.46 10.00 25.48 0.26 0.66 P.O. 20 mg tablet under fasting conditions Healthy subjects 34 [21]
Trimethoprim 290.32 10.00 34.44 2.70 9.30 P.O. 400:2000 mg trimethoprim: sulfamethoxazole Healthy subjects 24 [22]
Ivermectin 875.10 10.00 11.43 0.08 0.09 P.O. 12 mg solution Healthy subjects 11 [23]
Azithromycin 749.00 10.00 13.35 0.40 0.53 P.O. 500 mg Healthy subjects 12 [24,25]
Clarithromycin 747.95 10.00 13.37 2.85 3.81 P.O. 500 mg Healthy subjects 17 [26]
Ciprofloxacin 331.35 10.00 30.18 1.10 3.32 P.O. 200 mg Healthy subjects 12 [27]
Erythromycin 733.93 10.00 13.63 3.49 4.75 P.O. 800 mg every 12 h for 3 doses Healthy subjects 23 [28]
Roxithromycin 837.05 10.00 11.95 9.70 11.59 P.O. 300 mg Healthy subjects 20 [29]
Vancomycin 1449.30 10.00 6.90 10.00 6.90 I.V. 10 mg/kg Patients 6 [30]
Hydroxychloroquine 335.87 10.00 29.77 3.30 9.83 I.V. 310 mg over 0.5 h Healthy subjects 4 [31]