Table 1.
In vivo concentration ranges of the study compounds.
| Name of compound | Molecular weight | Concentration use in this study | In vivo Cmax | Dose | Subjects | N | Reference | ||
|---|---|---|---|---|---|---|---|---|---|
| g/mol | μg/mL | μM | μg/mL | μM | |||||
| Aripiprazole | 448.39 | 10.00 | 22.30 | 0.14 | 0.31 | P.O. 10 mg/day tablets | Healthy subjects | 24 | [17] |
| Ziprasidone | 412.94 | 10.00 | 24.22 | 0.09 | 0.22 | P.O. 40 mg tablets | Healthy subjects | 10 | [18] |
| CBN | 310.43 | 10.00 | 32.21 | 0.01 | 0.02 | Case report | – | – | [19] |
| THC | 314.45 | 10.00 | 31.80 | 1.10 | 3.50 | Case report | – | – | [19] |
| CBD | 314.47 | 10.00 | 31.80 | 1.39 | 4.40 | P.O. 1500 mg CBD twice daily | Healthy subjects | 9 | [20] |
| Dexamethasone | 392.46 | 10.00 | 25.48 | 0.26 | 0.66 | P.O. 20 mg tablet under fasting conditions | Healthy subjects | 34 | [21] |
| Trimethoprim | 290.32 | 10.00 | 34.44 | 2.70 | 9.30 | P.O. 400:2000 mg trimethoprim: sulfamethoxazole | Healthy subjects | 24 | [22] |
| Ivermectin | 875.10 | 10.00 | 11.43 | 0.08 | 0.09 | P.O. 12 mg solution | Healthy subjects | 11 | [23] |
| Azithromycin | 749.00 | 10.00 | 13.35 | 0.40 | 0.53 | P.O. 500 mg | Healthy subjects | 12 | [24,25] |
| Clarithromycin | 747.95 | 10.00 | 13.37 | 2.85 | 3.81 | P.O. 500 mg | Healthy subjects | 17 | [26] |
| Ciprofloxacin | 331.35 | 10.00 | 30.18 | 1.10 | 3.32 | P.O. 200 mg | Healthy subjects | 12 | [27] |
| Erythromycin | 733.93 | 10.00 | 13.63 | 3.49 | 4.75 | P.O. 800 mg every 12 h for 3 doses | Healthy subjects | 23 | [28] |
| Roxithromycin | 837.05 | 10.00 | 11.95 | 9.70 | 11.59 | P.O. 300 mg | Healthy subjects | 20 | [29] |
| Vancomycin | 1449.30 | 10.00 | 6.90 | 10.00 | 6.90 | I.V. 10 mg/kg | Patients | 6 | [30] |
| Hydroxychloroquine | 335.87 | 10.00 | 29.77 | 3.30 | 9.83 | I.V. 310 mg over 0.5 h | Healthy subjects | 4 | [31] |