Table 3.

Differential diagnosis between systemic mastocytosis and gastrointestinal diseases

Symptoms	Differential diagnosis
Chronic diarrhea	Irritable bowel syndrome; Inflammatory bowel disease; Celiac disease; Thyreopathies (i.e. hyperthyroidism, medullary thyroid cancer); Pancreatopathyes
Epigastric pain, dyspepsia, heartburn	Functional dyspepsia; Peptic ulcer; Gastroesophageal reflux disease; H. pylori related gastritis; Zollinger-Ellison Syndrome
Flushing	Neuroendocrine neoplasms
Hepato-splenomegaly, portal hypertension	Cirrhosis; Non cirrhotic portal hypertension