Table 3.
Association of the clinical outcomes in relation to the timing of biliary drainage and severity grading by Tokyo guidelines 2018
|
Severity of AC
|
Characteristic-median (IQR)
|
Drainage
|
Absence of drainage
|
P
value
|
Drainage < 12 h
|
Drainage > 12 h or absence
|
P
value
|
Drainage < 24 h
|
Drainage > 24 h or absence
|
P
value
|
Drainage < 48 h
|
Drainage > 48 h or absence
|
P
value
|
|
| Grade I | IHM | 0/302 | 1/131 | 0.303 | 0/54 | 1/379 | 1.000 | 0/128 | 1/305 | 1.000 | 0/199 | 1/234 | 1.000 | |
| LOS (d) | 11 (9-15) | 7 (4-10) | < 0.001 | 11 (8-13.25) | 10 (8-14) | 0.778 | 11 (8-14) | 10 (7-14) | 0.004 | 11 (8-14) | 10 (6-14) | 0.002 | ||
| Survivors’ LOS (d) (n = 387) | 12 (9-15) | 8 (5-11) | < 0.001 | 11 (8-13.25) | 11 (8-14) | 0.794 | 11 (9-14) | 11 (8-14) | 0.065 | 11 (9-14) | 10 (8-14) | 0.101 | ||
| Hospitalization cost (CNY) | 42845.67 (33734.18-52209.23) | 15763.10 (7737.32-23680.31) | < 0.001 | 43328.59 (32863.61-49384.19) | 35317.71 (18848.59-46850.08 | 0.001 | 44154.19 (35638.76-52219.56) | 31292.68 (16269.75-44599.67) | < 0.001 | 42908.34 (33358.44-50564.68) | 25519.43 (12347.06-42424.96) | < 0.001 | ||
| Survivors’ hospitalization cost (CNY) (n = 387) | 42957.18 (33973.58-52224.73) | 16596.85 (9096.73-24755.65 | < 0.001 | 43462.72 (36174.00-49384.19) | 36604.86 (21962.98-47554.27) | 0.003 | 44443.3 (35988.02-52237.14) | 33492.6 (46019.17-18880.26) | < 0.001 | 43264.07 (34606.54-51093.62) | 29762.32 (16376.75-44463.21) | < 0.001 | ||
| Grade II | IHM | 2/306 | 5/99 | 0.011 | 0/69 | 7/336 | 0.608 | 0/139 | 7/266 | 0.101 | 1/193 | 6/212 | 0.125 | |
| LOS (d) | 11 (9-15) | 7 (4-12) | < 0.001 | 11 (8-14) | 11 (7-14) | 0.684 | 11 (9-14) | 10 (7-14) | 0.122 | 11 (8-14) | 10 (7-14.8) | 0.190 | ||
| Survivors’ LOS (d) (n = 349) | 12 (9-15) | 7.5 (4.75-11.25) | < 0.001 | 11.5 (9-14) | 11 (8-14) | 0.367 | 12 (10-14) | 11 (7-14) | 0.024 | 12 (9-14) | 11 (7-14) | 0.050 | ||
| Hospitalization cost (CNY) | 44033.13 (31071.05-56134.72) | 17626.20 (10037.69-25587.43) | < 0.001 | 45832.44 (36061.53-56949.37) | 36132.93 (21795.89-51453.62) | < 0.001 | 46789.09 (35989.59-57723.15) | 31505.72 (19948.31-47463.61) | < 0.001 | 45489.74 (33858.99-57600.43) | 29275.30 (16928.45-46255.47) | < 0.001 | ||
| Survivors’ hospitalization cost (CNY) (n = 349) | 45004.20 (32631.09-56660.62) | 16342.15 (10300.68-25017.80) | < 0.001 | 47938.00 (37937.29-58046.02) | 36629.15 (22828.93-51509.37) | < 0.001 | 48254.61 (37937.29-58929.51) | 31589.96 (20386.80-47062.76) | < 0.001 | 46564.37 (36191.07-57998.63) | 29338.38 (17687.02-45685.12) | < 0.001 | ||
| Grade III | IHM | 11/307 | 22/160 | < 0.001 | 3/89 | 30/378 | 0.168 | 7/178 | 26/289 | 0.041 | 9/225 | 24/242 | 0.018 | |
| LOS (d) | 13 (9-17) | 8 (3-12) | < 0.001 | 13 (11-19) | 11 (6-15) | < 0.001 | 13 (10-17) | 10 (6-14) | < 0.001 | 13 (9-17) | 9.5 (5-14) | < 0.001 | ||
| Survivors’ LOS (d) (n = 351) | 13 (11-18) | 9.5 (7-13.25) | <0.001 | 13 (12-19) | 12 (9-16) | 0.001 | 13 (11-17.75) | 12 (9-15) | < 0.001 | 13 (11-17.75) | 11 (8-15) | < 0.001 | ||
| Hospitalization cost | 51583.64 (38985.47-64886.01) | 20183.58 (11317.37-29525.99) | < 0.001 | 56599.94 (43260.73-70300.00) | 38527.58 (21034.79-55279.53) | < 0.001 | 55121.49 (40428.29-67707.01) | 31832.99 (17933.81-50037.89) | < 0.001 | 54295.52 (39252.57-65638.57) | 28165.23 (15708.29-45478.26) | < 0.001 | ||
| Survivors’ hospitalization cost (CNY) (n = 351) | 53507.33 (41027.94-65312.29) | 22909.77 (15594.93-31845.39) | < 0.001 | 57976.4 (50131.44-70333.71) | 43241.54 (28347.56-57860.29) | < 0.001 | 55873.84 (46654.40-69946.73) | 38973.06 (24292.41-53090.85) | < 0.001 | 55782.38 (43994.26-66493.67) | 34748.29 (21379.37-50147.24) | < 0.001 | ||
AC: Acute cholangitis; IQR: Interquartile range; IHM: In-hospital mortality; LOS: Length of stay; CNY: Chinese Yuan.