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. 2022 Aug 7;28(29):3854–3868. doi: 10.3748/wjg.v28.i29.3854

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Changes in nitric oxide synthase concentration in colonic myenteric tissue and serum. A: Comparison of nitric oxide synthase (NOS) concentration in colonic myenteric tissue of rats in the four groups showing statistically significant differences between EG groups and CG group (^bP < 0.0001), and between EG2-3 groups and EG1 group (^aP < 0.05); B: Comparison of NOS concentrations in the serum of rats in the four groups showing statistically significant differences between EG groups and CG group (^bP < 0.0001), and between EG2-3 groups and CG group (^aP < 0.05). CG: Control group; UC: Ulcerative colitis; NOS: Nitric oxide synthase; L-NMMA: NG-monomethyl-L-arginine monoacetate; EG1: UC group; EG2: UC + NOS agonist TP508TFA group; EG3: UC + NOS inhibitor L-NMMA group; NOS: Nitric oxide synthase.