Figure 5.

Evaluation of the impact of intrarectal instillation of flagellin on colonic sensitivity. A: Intracolonic pressure variation (IPV) in response to colorectal distension in males mice before (Baseline) and after (30, 60 and 120 min) intrarectal instillation of flagellin (5 µg); B: Area under the curve (AUC) of the IPV relative to highest colorectal distension pressures (60, 80 and 100 mmHg). For each mouse and each time point, n = 10. ^aP < 0.05, ^bP < 0.01 and ^cP < 0.001 respect to Baseline. For IPV to colorectal distension test, dots represent means and error bars represent SEM. For AUC, each dot represents one mouse and red lines represent means.