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. 2022 Aug 3;14(15):3776. doi: 10.3390/cancers14153776

Figure 3.

Figure 3

Exosomes from serum of EGFR-mutated patients promote extracellular matrix degradation and EMT-like process (A–C) Quantification analysis of expression of MMPs obtained by zymography in exosomes isolated from serum (mean ± SEM, n = 5). (D,E) Quantification analysis of vimentin and E-cadherin expression obtain by Western blotting of protein extracts of A549 cells treated with exosomes isolated from serum. GAPDH is used as a loading control (mean ± SEM, n = 5). (F–H) Quantification analysis of expression of MMPs obtained by zymography of supernatant of A549 cells treated with exosomes isolated from serum (mean ± SEM, n = 5). Significance was set at * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001.