Table 2.
The diagnostic performance of various technologies for TP and TRCs, and related parameter thresholds.
| Study | TP | TRCs | Modality Imaging |
Parameter | Cut-off for TP | Sensitivity | Specificity | Accuracy |
|---|---|---|---|---|---|---|---|---|
| Lee et al. [41] | 10 | 12 | DWI | Mean ADC | 1200 × 10−6 mm2/s | 80.0% | 83.3% | 81.2% |
| Yoo et al. [25] | 24 | 18 | DWI | The 5th percentile of ADC (b = 1000) | 915 × 10−6 mm2/s | 83% | 67% | - |
| Chu et al. [43] | 15 | 15 | DWI | The 5th percentile of ADC (b = 3000) | 645 × 10−6 mm2/s | 93.33% | 100% | 88.9% |
| Kim et al. [49] | 31 | 20 | IVIM | Mean 90th percentile for perfusion (f) Mean 90th percentile for nCBV |
0.056 2.892 |
87.1% 83.9% |
95.0% 95.0% |
- - |
| Kong et al. [68] | 33 | 26 | DSC | Mean rCBV | 1.47 | 81.5% | 77.8% | - |
| Baek et al. [70] | 42 | 37 | DSC | Skewness and kurtosis of normalized CBV | 1.27 | 85.7% | 89.2% | - |
| Yun et al. [79] | 17 | 16 | DCE | Mean Ktrans/mean Ve | 0.347/0.570 | 59%/88% | 94%/56% | - |
| Yoo et al. [75] | 16 | 8 | DCE | Mean Ve | 0.873 | 100% | 63% | 88% |
| Thomas et al. [77] | 24 | 13 | DCE | Vp90%/mean Vp/mean Ktrans | 3.9/3.7/3.6 | 92%/85%/69% | 85%/79%/79% | - |
| Bisdas et al. [78] | 12 | 6 | DCE | Ktrans/IAUC | 0.91/15.35 | 100%/75% | 83%/67% | - |
| Suh et al. [76] | 43 | 36 | DCE | mAUCRH/50thAUCR | 0.31/0.19 | 90.1%/87.2% | 82.9%/83.1% | - |
| Chung et al. [72] | 32 | 25 | DCE | mAUCRH/90thAUCR | 0.23/0.32 | 93.8%/90.6% | 88%/88% | - - |
| Ma et al. [93] | 20 | 12 | APT | APTmean/APTmax | 2.42/2.54 | 85.0%/95% | 100%/91.7% | - |
| Choi et al. [82] | 34 | 28 | ASL/DSC | CBF/normalized rCBV | - | 94.1% | 82.1% | 88.7% |
| Nael et al. [101] | 34 | 12 | DWI/DSC/DCE | rCBV/Ktrans | 2.2/0.08 | 94.1 | 91.6 | 92.8 |
| Razek et al. [56] | 24 | 18 | ASL/DTI | CBF/FA/MD | - | 93.8% | 95.8% | 95% |
| Seeger et al. [73] | 23 | 17 | DSC/DCE/ASL/MRS | normalized rCBV or rCBF /Ktrans/rCBF/Cho/Crn | rCBV ≥ 3.9 or rCBF ≥ 4.1, Ktrans ≥ 0.08, rCBF ≥ 2.5, Cho/Crn ≥ 1.89 |
82.6% |
100% | 90% |
| Wang et al. [58] | 21 | 20 | DSC/DTI | FA/CL/rCBVmax | 0.55 | 76% | 95% | - |
| Prager et al. [6] | 58 | 10 | DWI/DSC | ADC/normalized rCBV | ADC ≤ 1.49 × 10−3 mm2/s/rCBV ≥1.27 | 51.2% | 100% | - |
| Park et al. [102] | 45 | 63 | DWI/DSC/DCE | 10th percentileof ADC (ADC10)/ 90th percentile of normalized rCBV (nCBV90)/ 90th percentile of IAUC (IAUC90) |
ADC10 < 1.14 × 10 mm2/s/ nCBV90 of 3.19/ IAUC90 of 19.42/ total cluster score of 5.91 |
91.1% | 90.5% | 90.7% |