Table 1.
Differences in immunohistochemistry protein losses in tumors with microinstability in endometrial cancer using the expression of two proteins.
| Reference | Type of Tissue | Germinal Mutation Included | MMRd (n) | MMRd (%) | MLH1 (%) | MSH2 (%) | MSH6 (%) | PMS2 (%) | MLH1 Promoter Methylation (%) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Simpkins 1999 [19] | FPPE + frozen tissue | 0 | 53 | 100 | 14.3 | 86 | - | - | 77 | |
| Peiro 2001 [20] | FFPE | 0 | 12 | 13.5 | 12.4 | 1.1 | - | - | - | |
| Maruyama 2001 [21] | FFPE | 1 | 31 | 37 | 12 | 19 | - | - | - | |
| Berends 2001 [22] | FFPE | 1 | 13 | 27 | 61.5 | 30.7 | - | - | - | |
| Chiaravalli 2001 [23] | FFPE | 1 | 13 | 39.4 | - | - | - | - | - | |
| Hardisson 2003 [24] | FFPE | 0 | 23 | 29.5 | 73.9 | 21.7 | - | - | - | |
| Sutter 2004 [25] | Frozen tissue | 1 | 13 | 39.4 | 20 | 76.9 | - | - | - | |
| Irving 2005 [26] | FFPE | 0 | 6 | 50 | 83.3 | 16.7 | - | - | 83 | |
| Alvarez 2012 [27] | FFPE + frozen Tissue | 0 | 4 | 16 | 75 | 25 | - | - | - | |
| Plotkin 2020 [28] | FFPE | 0 | 11 | 22 | - | - | 0 | 100 | - | |
FFPE: formalin-fixed paraffin-embedded, MMRd: mismatch repair-deficient.