Table 2.
Differences in immunohistochemistry protein losses in tumors with microinstability in endometrial cancer using the expression of three proteins.
| Reference | Type of Tissue | Germinal Mutation Included | MMRd (n) | MMRd (%) | MLH1 (%) | MSH2 (%) | MSH6 (%) | PMS2 (%) | MLH1 Promoter Methylation |
|---|---|---|---|---|---|---|---|---|---|
| Planck 2002 [29] | FFPE | 1 | 21 | - | 9.5 | 47.6 | 57.1 | - | - |
| Orbo 2003 [30] | FFPE | 0 | 18 | - | 55.5 | 22.2 | 33.3 | - | - |
| Lipton 2004 [31] | Healthy tissue | 1 | 67 | 27 | 44.8 | 43.3 | 1.5 | - | - |
| Macdonald 2004 [32] | FFPE + frozen | 0 | 164 | 51.9 | 14 | 19 | 17 | - | 69 |
| Buttin 2004 [33] | Frozen tissue + healthy tissue | 1 | 94 | 22.8 | - | - | - | - | 70 |
| Soliman 2005 [34] | FPPE | 1 | 12 | 20 | 58.3 | 41.7 | 41.7 | - | - |
| Cederquist 2005 [35] | FFPE | 1 | 6 | 100 | 0 | 0 | 66.7 | - | - |
| Ollikainen 2005 [36] | FFPE + healthy tissue | 1 | 16 | 48.5 | 43.8 | 25 | 31.3 | - | - |
| Taylor 2006 [37] | FPPE | 0 | 6 | 21 | 33.3 | 0 | 0 | - | - |
| Niessen 2006 [38] | Not described | 0 | 36 | 17.1 | 30.6 | 13.9 | 55.6 | - | - |
| Rijcken 2006 [39] | FFPE | 1 | 18 | 100 | 33.3 | 11.1 | 11.1 | - | - |
| Yoon 2008 [40] | FFPE + healthy tissue | 1 | 50 | 44.2 | 46 | 4 | 2 | - | 14 |
| Arabi 2009 [41] | FFPE + healthy tissue | 0 | 25 | 21 | 22.5 | 18 | 43 | - | - |
| Walsh 2010 [42] | FFPE | 1 | 9 | 12.5 | 12 | 2 | 6 | - | - |
| Yasue 2011 [43] | FFPE + frozen tissue | 0 | 8 | 22.9 | 100 | 25 | 45.8 | - | - |
| Huang 2014 [44] | FFPE | 1 | 29 | - | 27.6 | 55.2 | 17.2 | - | - |
| Kobayashi 2015 [45] | FFPE | 0 | 17 | 53.1 | 82.4 | 11.8 | 64.7 | - | - |
| Ren 2020 [46] | FFPE | 1 | 27 | 12.8 | 38.1 | 37 | 51.8 | - | 33.3 |
FFPE: formalin-fixed paraffin-embedded, MMRd: mismatch repair-deficient.