Table 3.
Differences in immunohistochemistry protein losses in tumors with microinstability in endometrial cancer using expression of four proteins.
| Reference | Type of Tissue | Germinal Mutation Included | MMRd (n) | MMRd (%) | MLH1 (%) | MSH2 (%) | MSH6 (%) | PMS2 (%) | MLH1 Promoter Methylation (%) |
|---|---|---|---|---|---|---|---|---|---|
| Westin 2008 [47] | FFPE | 1 | 12 | 34.3 | 25 | 75 | 75 | 25 | 16.7 |
| Matthews 2008 [48] | FFPE + healthy tissue | 1 | 21 | 34.4 | 85.7 | 95.3 | 23.8 | 76.2 | - |
| Garg 2009 [49] | FFPE | 0 | 9 | 20 | 33.3 | 33.3 | 50 | 44.4 | - |
| Garg 2009 [50] | FFPE | 1 | 32 | 45 | 59.4 | 40.6 | 40.6 | 59.4 | - |
| Tafe 2010 [51] | Not described | 1 | 8 | 47 | 87.5 | 0 | 12.5 | 87.5 | - |
| Cossio 2010 [52] | FFPE + healthy tissue | 1 | 7 | 30 | 28.6 | 14.3 | 71.4 | 28.6 | - |
| Resnick 2010 [53] | FFPE | 0 | 155 | 66.5 | - | - | - | - | |
| Shih 2011 [54] | FFPE | 1 | 9 | 16.1 | 44.4 | 55.6 | 55.6 | 44.4 | - |
| Leenen 2012 [55] | FFPE | 1 | 42 | 23.5 | 76.2 | 23.8 | 23.8 | 23.8 | 73.8 |
| Soslow 2012 [56] | FFPE | 0 | 7 | 31.8 | 100 | 0 | 0 | 100 | - |
| Egoavil 2013 [57] | FFPE | 1 | 61 | 33.5 | 72.1 | 8.2 | 21.3 | 13.1 | 55.7 |
| Bosse 2013 [58] | FFPE | 1 | 36 | 24.7 | - | - | - | - | 88.9 |
| Moline 2013 [59] | FFPE | 1 | 59 | 24.1 | 84.7 | 15.3 | 18.6 | 15.3 | 55.9 |
| Peiro 2013 [60] | FFPE | 1 | 63 | 24.4 | 79.4 | 4.8 | 17.6 | 79.4 | - |
| Romero-Perez 2013 [61] | FFPE | 0 | 39 | 32.5 | 48.7 | 23.1 | 30.8 | 69.2 | - |
| Mills 2014 [62] | FFPE | 1 | 137 | 22.6 | 72.3 | 27 | 27 | 72.3 | - |
| Ruiz 2014 [63] | FFPE | 0 | 64 | 30.2 | 54.7 | 6.3 | 54.7 | 56.3 | - |
| Thoury 2014 [64] | FFPE + healthy tissue | 0 | 17 | 24.6 | 65 | 0 | 23 | 59 | - |
| Rabban 2014 [65] | FFPE | 1 | 41 | 15 | 75.6 | 7.7 | 17 | 7.3 | - |
| Long 2014 [66] | Not described | 1 | 41 | 23.7 | 24.4 | 51.2 | 68.3 | 31.7 | - |
| Woo 2014 [67] | FFPE | 0 | 15 | 19.5 | 86.7 | 13.3 | 13.3 | 86.7 | - |
| Hoang 2014 [68] | FFPE | 0 | 6 | 9.5 | 50 | 16.7 | 16.7 | 83.3 | - |
| Buchanan 2014 [69] | FFPE | 1 | 170 | 24 | 75 | 13 | 24.7 | 75.3 | - |
| Allo 2014 [70] | FFPE | 0 | 63 | 33 | 73 | 15.9 | 23.8 | 73 | - |
| Goodfellow 2015 [71] | FFPE + Frozen tissue | 1 | 360 | 38.4 | 75.2 | 3.1 | 11.9 | 7.5 | 70.3 |
| Chu 2015 [72] | FFPE + frozen tissue + healthy tissue | 0 | 22 | 32.8 | 27.2 | 22.7 | 72.3 | 27.2 | - |
| Graham 2015 [73] | FFPE + healthy tissue | 1 | - | - | - | - | - | - | - |
| Dudley 2015 [74] | FFPE | 1 | 72 | 33.4 | - | - | - | 20.8 | - |
| Stelloo 2015 [75] | FFPE | 0 | 19 | 16.4 | 63.2 | - | - | - | 47.4 |
| Mao 2015 [76] | Not described | 0 | 19 | 46.3 | 73.7 | 10.5 | 15.8 | 78.9 | - |
| Mc Conechy 2015 [77] | Frozen tissue | 0 | 38 | 24.2 | 50 | 5.3 | 10.5 | 55.3 | - |
| Stewart 2015 [78] | FFPE | 0 | 13 | 59.1 | 76.9 | 15.4 | 30.8 | 84.7 | - |
| Watkins 2016 [79] | FFPE | 1 | 27 | 21.6 | 88.9 | 3.7 | 14.8 | 44.4 | 25.9 |
| Pocrnich 2016 [80] | Not described | 1 | 8 | 44.4 | 75 | 12.5 | 12.5 | 75 | - |
| Lin 2016 [81] | Not described | 1 | 17 | 22.3 | 82.3 | 17.6 | 17.6 | 82.3 | 64.7 |
| Mills 2016 [82] | Not described | 1 | 66 | 31.4 | 65.2 | 18.2 | 31.8 | 71.2 | - |
| Ramalingam 2016 [83] | FFPE | 0 | 18 | 51.4 | 94.4 | 5.6 | 5.6 | 94.4 | - |
| Shikama 2016 [84] | FFPE | 1 | 62 | 28 | 62.9 | 14.5 | 38.7 | 67.7 | - |
| Kato 2016 [85] | FFPE | 1 | 8 | 2.2 | - | - | - | - | - |
| Okoye 2016 [86] | FFPE | 0 | 40 | 9.7 | - | - | - | - | 75 |
| Russo 2017 [87] | FFPE + healthy tissue | 0 | 3 | 50 | 66.7 | 33.3 | 33.3 | 66.7 | - |
| Bregar 2017 [88] | FFPE | 0 | 13 | 18.5 | - | 0 | 0 | - | - |
| Pelletier 2017 [89] | Not described | 0 | 34 | 26.8 | 67.6 | 8.8 | 14.7 | 85.3 | - |
| Stelloo 2017 [90] | FFPE | 0 | 169 | 24.3 | 85.2 | 5.9 | 13.6 | 89.9 | - |
| Dillon 2017 [91] | FFPE | 1 | 60 | 26 | 85 | 3.3 | 3.3 | 85 | 81.2 |
| Tangjitgamol 2017 [92] | FFPE | 0 | 212 | 55.1 | 60.4 | 29.7 | 70.3 | 62.3 | - |
| Zakhour 2017 [93] | FFPE | 1 | 6 | 7.1 | 33.3 | 50 | 66.7 | 33.3 | - |
| Najdawi 2017 [94] | FFPE | 1 | 36 | 29 | 86.7 | 13.9 | 26.7 | 93.3 | - |
| Sloan 2017 [95] | FFPE | 1 | 38 | 56.7 | - | - | - | - | 15.8 |
| Watkins 2017 [96] | FFPE | 1 | 48 | 19.8 | 81.3 | 8.3 | 14.6 | 85.4 | - |
| Chen 2017 [97] | FFPE | 0 | 30 | 10.3 | - | - | - | - | - |
| Kobel 2017 [98] | FFPE | 0 | 6 | 37.5 | 50 | 33.3 | 50 | 33.3 | - |
| Pina 2018 [99] | Not described | 1 | 242 | 27.1 | 78.9 | 21.1 | 21.1 | 78.9 | 69 |
| Adar 2018 [100] | Not described | 1 | 107 | 22.1 | 80.3 | 19.6 | 19.6 | 15.4 | 70 |
| Chapel 2018 [101] | FFPE | 1 | 30 | 30.3 | 86.7 | 10 | 10 | 90 | - |
| Bosse 2018 [102] | Not described | 0 | 136 | 36.2 | - | - | - | - | - |
| Saita 2018 [103] | Not described | 1 | 13 | - | 46.2 | 23.1 | 30.8 | - | - |
| Espinosa 2018 [104] | FFPE | 0 | 2 | 50 | 100 | 0 | 0 | 100 | - |
| Li 2018 [105] | FFPE | 0 | 162 | 23.1 | 80.2 | 19.8 | 19.8 | 80.2 | - |
| Doghri 2019 [106] | FFPE | 0 | 10 | 22.2 | 80 | 10 | 10 | 80 | - |
| Hashmi 2019 [107] | FFPE | 1 | 56 | 44.4 | 92.9 | 17.9 | 35.7 | 89.3 | - |
| Saeki 2019 [108] | FFPE + healthy tissue | 0 | 18 | 18.4 | 77.8 | 22.2 | 44.4 | 83.3 | - |
| Zannoni 2019 [109] | FFPE | 0 | 15 | 33.3 | 0 | 46.7 | 73.3 | 26.7 | - |
| Abdufatah 2019 [110] | Not described | 0 | 20 | 40 | 5 | 10 | 80 | 80 | - |
| Chapel 2019 [111] | FFPE | 1 | 17 | 100 | 94.1 | 5.9 | 5.9 | 94.1 | - |
| Kahn 2019 [112] | Not described | 1 | 1672 | 28.3 | 69.3 | - | - | - | 53.9 |
| Ryan 2019 [113] | Not described | 1 | 2563 | 24.5 | 17.5 | 3 | 3 | 2 | 37.6 |
| Wu 2019 [114] | FFPE | 1 | 50 | 100 | 63 | 10 | 24 | 72 | - |
| Saijo 2019 [115] | FFPE | 0 | 6 | 10.5 | - | - | - | - | - |
| Sarode 2019 [116] | FFPE | 1 | 45 | 9.3 | - | - | - | - | 26.7 |
| Sari 2019 [117] | FFPE | 0 | 22 | 30 | 68.2 | 9 | 13.6 | 68.2 | - |
| Lucas 2019 [118] | FFPE | 1 | 63 | - | 54 | 19 | 42.9 | 55.6 | - |
| Baniak 2019 [119] | FFPE | 0 | 0 | - | - | - | - | - | - |
| Backes 2019 [120] | Not described | 0 | 64 | 32.5 | - | - | - | - | - |
| Dong 2019 [121] | FFPE | 0 | 63 | 24 | - | - | - | - | - |
| Gan 2019 [122] | FFPE | 1 | 91 | 27.2 | 87.9 | 12.1 | 12.1 | 87.9 | 69.2 |
| He 2019 [123] | Not described | 1 | 2 | 3.3 | - | ||||
| Ryan 2020 [124] | FFPE + healthy tissue | 1 | 132 | 26 | 75.8 | 9.1 | 18.9 | 75.8 | 62.9 |
| Rosa 2020 [125] | FFPE | 1 | 80 | 33.1 | 51.3 | 12.5 | 22.5 | 43.8 | 48.8 |
| Beinse 2020 [126] | FFPE | 0 | 35 | 29.7 | - | - | 17 | 83 | - |
| Timmerman 2020 [127] | Not described | 1 | 33 | 31 | 81.8 | 3 | 15.2 | 6.1 | 79 |
| Missaoui 2020 [128] | FFPE | 1 | 1 | 3.7 | 100 | - | - | 100 | 100 |
| Dasgupta 2020 [129] | Not described | 1 | 4 | - | 100 | - | - | 100 | - |
| Kolehmainen 2020 [130] | FFPE | 0 | 287 | 47.5 | - | - | - | - | - |
| León-Castillo 2020 [131] | FFPE | 0 | 137 | 33.4 | - | - | - | - | - |
| Rekhi 2020 [132] | FFPE | 0 | 50 | - | 66 | 28 | 28 | 66 | - |
| Kim 2020 [133] | FFPE | 0 | 5 | 9.6 | - | - | - | - | - |
| Pasanen 2020 [134] | FFPE + tumor cells | 0 | 191 | 37.3 | - | - | - | - | - |
| Jin 2020 [135] | Not described | 0 | 1 | 5 | - | - | - | - | - |
| Rowe 2020 [136] | FFPE | 1 | 43 | - | - | - | - | - | 46.5 |
| Stinton 2021 [137] | Not described | 1 | - | - | - | - | - | - | - |
| Pecriaux 2021 [138] | FFPE | 1 | 9 | 60 | 100 | 0 | 0 | 88.9 | - |
| Tjalsma 2021 [139] | Not described | 1 | 41 | 23 | 14 | 9 | 9 | 14 | 14 |
| Joehlin-Price 2021 [140] | FFPE | 1 | 35 | 36.8 | 77.1 | 11.4 | 25.9 | 77.1 | 20 |
| Yamamoto 2021 [141] | FFPE | 1 | 68 | 17.2 | 77.9 | 16.2 | 17.6 | 79.4 | 75 |
FFPE: formalin-fixed paraffin-embedded, MMRd: mismatch repair-deficient.