Table 4.

Reports on prognostic factors in patients with ER for EGC.

Authors, Year	Study Population	No. of Subjects	Study Design	Prognostic Factors
Yoshifuku et al., 2016 [91]	≥85 years	85	Single-center, retrospective	ASA-PS ≥ 2
Sekiguchi et al., 2017 [92]	≥85 years	108	Single-center, retrospective	PNI < 44.6
Iwai et al., 2018 [93]	All	585	Single-center, retrospective	CCI ≥ 3, ECOG-PS ≥ 2, PNI < 47.7
Toya et al., 2019 [94]	≥75 years, non-curative ER	87	Single-center, retrospective	CCI ≥ 3
Tanoue et al., 2019 [95]	PS-matched cohort	178	Single-center, retrospective	ASA-PS = 3.
Ogata et al., 2022 [96]	All (including surgery)	1439	Single-center, retrospective	Early mortality: age ≥ 85 years, CCI ≥ 2, ASA-PS ≥ 3, ECOG-PS ≥ 2, CAR ≥ 0.028, eCuraC-2-intermediate/high 1, low PMI; Late mortality: age ≥ 75 years, CCI ≥ 2, ASA-PS ≥ 3, ECOG-PS ≥ 2, CAR ≥ 0.028
Miyahara et al., 2022 [97]	≥80 years (including surgery)	535	Single-center, retrospective	age > 80 years, male, ECOG-PS ≥ 2, CCI ≥ 2, BMI ≤ 21.875, PNI ≤ 46.7
Waki et al., 2022 [98]	≥75 years	400	Single-center, retrospective	ECOG-PS ≥ 2, PNI < 49.1, eCuraC-2
Toya et al., 2022 [99]	≥85 years	740	Multicenter, retrospective	GNRI, CCI

¹ Pathological risk classification among patients with non-curative ER (eCuraC-2) was based on the eCura system [65]. ASA-PS, American Society of Anesthesiologists physical status; BMI, body mass index; CAR, C-reactive protein/albumin ratio; CCI, Charlson comorbidity index; ECOG-PS, Eastern Cooperative Oncology Group performance status; EGC, early gastric cancer; ER, endoscopic resection; GNRI, Geriatric Nutritional Risk Index; PMI, psoas muscle mass index; PNI, prognostic nutrition index; PS, propensity score.