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. 2022 Aug 8;14(15):3840. doi: 10.3390/cancers14153840

Figure 8.

Figure 8

Photodynamic therapy in gallbladder cancer. (A) Accumulation of fluorescence imaging in mouse subcutaneous tumors after administration of ICG or ICG-lactosomes was observed daily using in vivo imaging systems. On the second day following administration, PDT was performed in groups with ICG (n = 5, open circles) and single (ICG-Lact1, n = 5, closed squares) or double PDT with ICG-lactosomes (ICG-Lact2, n = 5, closed triangles). The second irradiation was performed on day 5. (B) Effect of PDT on tumor growth in mice with subcutaneous tumors treated with ICG and ICG-lactosomes. On the second day following administration, PDT was performed in the ICG (n = 8, open circles) and ICG-Lact1 (n = 8, closed squares) groups. The second PDT was performed 3 days after the first PDT in the ICG-Lact2 group (n = 8, closed triangles). * p < 0.001 between the ICG and ICG-Lact2 groups. † p < 0.05 between the ICG and ICG-Lact1 groups. ‡ p < 0.05 between the ICG-Lact1 and ICG-Lact2 groups. (Reproduced from Hishikawa et al. [24]).