Table 3.

Selected common interactors of DDX3X and DDX5 and their roles in tumorigenesis.

Interactor	Function	Tumor-Specific Interactome	Role 1	Mechanism	Roles of DDX3X/DDX5 in the Same Tumor 1	Ref.
RPA2	ss DNA-binding protein	Breast Cancer	+	NF-κB activation	+/+	[92,93]
CTCF	Transcriptional coactivator	Breast Cancer	−	Regulation of transcription	+/+	[94,95]
DHX9	RNA/DNA helicase	Breast Cancer	+	Upregulation of lncRNA	+/+	[96,97]
CUL1	Ubiquitination cofactor	Breast Cancer	+	Positive regulation of proliferation	+/+	[98]
CUL5	Ubiquitination cofactor	Breast Cancer	−	Negative regulation of proliferation	+/+	[99]
YBX1	Transcription factor	Breast Cancer	+	Interaction with lncRNA AC073352.1	+/+	[100]
RPS6KB2	Protein kinase	Breast Cancer	+	Activation of estrogen receptor-alpha	+/+	[101,102]
AGR2	Disulfide isomerase	Breast Cancer	+	Aberrant protein maturation in the ER	+/+	[103,104]
YY1	Transcription factor	Cervical cancer	Dual	Gene-specific recruitment of transcriptional activators or repressors	?/+	[105]
CHD4	Chromatin remodeling	Endometrial cancer	−	Activation of the TGF-β pathway	?/+	[106]
TAF15	mRNA metabolism	Gastric cancer	+	Modulation of stress response	−/+	[107]
MATR3	DNA/RNA-binding protein	Lung cancer	+	Undetermined	Dual/+	[108,109,110]
DYRK2	Protein kinase	Glioblastoma	−	Negative regulation of cell migration	+/+	[111]
PINK1	Mitochondrial protein kinase	Glioblastoma	−	Negative regulation of oxidative stress	+/+	[112]
SYNCRIP	RNA-binding protein	Leukemia	+	Activation of oncogenes	+/+	[113]
ITGA4	Integrin	Leukemia	+	Upregulation of BCL-2/negative regulation of apoptosis	+/+	[114]
MED12	Protein kinase	Prostate cancer	+	Activation of Wnt/β-catenin and TGF-β signaling	+/+	[115]
CNEPA	Kinetochore subunit	Liver cancer	+	Aberrant chromosomal segregation	?/−	[116]

¹ (+) oncogene, (−) oncosuppressor; (dual) oncogene or oncosuppressor in different studies; (?), role unknown.