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. 2022 Jul 31;14(15):3747. doi: 10.3390/cancers14153747

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HAS2 downregulation impairs CD44-related genes and self-renewal capacity. (a) U251MG cells stably transfected with shRNAs against HAS2 or control shRNA were grown in sphere-like conditions. HAS2-AS1, HAS2, VEGFA, and LOX mRNAs were quantified by real-time qPCR analysis and normalized to HPRT. (b) An ELDA assay was carried out in the HAS2 knockdown and control cells, and cells treated with the hyaluronan synthesis inhibitor 4-MU or DAPT. One representative experiment out of two is depicted.