5-FU	5-fluorouracil
ADCs	antibody-drug conjugates
BRAF CEP17	v-raf murine sarcoma viral oncogene homolog B1 centromere enumeration probe for chromosome 17
CNS	central nervous system
CRC	colorectal cancer
ctDNA	circulating tumor DNA
EGF EGFR EREG	epidermal growth factor epidermal growth factor receptor epiregulin
ESMO	European Society of Medical Oncology
FISH	fluorescence in situ hybridization
FOLFIRI	5-fluouracil/leucovorin/irinotecan
FOLFOX	5-fluouracil/leucovorin/oxaliplatin
FOLFOXIRI	5-fluouracil/leucovorin/oxaliplatin/irinotecan
HER2	human epidermal growth factor receptor 2
IHC	immunochemistry
LV	leucovorin
m MAPK	month mitogen-activated protein kinase
mCRC	metastatic colorectal cancer
mPFS	median progression-free survival
NCCN	National Comprehensive Cancer Network
NGS	next-generation sequencing
NK	natural killer
NTRK	neurotrophic tyrosine receptor kinase
ORR	overall response rates
OS PI3K	overall survival phosphoinositide 3-kinase
PFS PTEN	progression-free survival phosphatase and tensin homolog
QT	chemotherapy
RAS RTK STAT	rat sarcoma virus receptor tyrosine kinase signal transducer and activator of transcription
T-DM1	trastuzumab emastine
TD	trastuzumab deruxtecan
TKIs	tyrosine kinase inhibitors
VEGF	anti-vascular endothelial growth factor
WT	wild-type