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. 2022 Jul 31;14(15):3738. doi: 10.3390/cancers14153738

Table A1.

Main conclusions of studies up to 2011 (reproduced from Anwar et al. [4]).

From Anwar 2013 Main Conclusions
1 Jensen et al. [31] AA is associated with poor survival
2 Abel et al. [32] APR for local control needed in most patients
3 Basik et al. (1995) [33] Improved survival through early diagnosis and radical surgery
4 Joon et al. (1999) [24] CRT preferred for early cancers and APR reserved for salvage surgery
5 Wolff and Peiffert [34] Gold standard for treatment should stay as APR
6 Belkacémi et al. (2003) [26] Recommend CRT for early cancers and APR for salvage surgery
7 Longo et al. [35] APR followed by CRT is optimal treatment
8 Anthony et al. [36] Combination of neoadjuvant CRT and APR is optimal treatment
9 Klas et al. [37] Tumours larger than 5 cm should be managed with surgery and CRT, smaller with S alone.
10 Beal et al. (2003) [30] APR and CRT combination is a reasonable approach to treatment
11 Papagikos et al. (2003) [29] Neoadjuvant CRT and APR combination, +/− adjuvant CT is the optimal treatment regimen
12 Li et al. [38] APR and postoperative CRT is suggested
13 Chang et al. (2009) [25] APR with neoadjuvant CRT is the most sensible management
14 Devon et al. [39] Recommend multimodality therapy
15 Iesalnieks et al. [27] For patients with CD and chronic perianal fistulae, cancer surveillance is essential
16 Wong et al. [40] Recommend S alone, with postoperative CRT for certain patients