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Design (A) and workflow of the data analyses (B) of the REVEAL study (M, post-therapeutic tissue, liver metastasis; N, normal tissue in the vicinity of the primary tumor; P, pre-therapeutic primary tumor; i-L, intra-therapeutic liquid biopsy; i/p-L, intra/post-therapeutic liquid biopsy); GO, gene ontology analysis; GSEA, gene set enrichment analysis; IGV, integrative genomics viewer; PCA, principal component analysis; QC, quality control.
