Table 2.
Significant DEGs identified in all samples (DEG A) and paired samples (DEG B).
| Gene | DEG | Log2 FC | Avg Expr | p Value | P adj | FC | %Change | Program/Pathway/Function |
|---|---|---|---|---|---|---|---|---|
| SFRP2 | A | −3.46 | 5.81 | 1.77 × 10−5 | 0.0016 | 0.09 | −90.91 | EMT/MET/WNT |
| B | −4.33 | 4.94 | 5.85 × 10−6 | 0.00065 | 0.05 | −95.03 | ||
| THBS4 | A | −3.44 | 4.55 | 3.98 × 10−7 | 8.81 × 10−5 | 0.09 | −90.79 | ER stress, tumor suppressor CRC |
| B | −4.52 | 4.05 | 7.26 × 10−7 | 0.00016 | 0.04 | −95.64 | ||
| MMP3 | A | −2.94 | 4.24 | 6.56 × 10−7 | 9.69 × 10−5 | 0.13 | −86.97 | ECM modulating/related |
| B | −4.11 | 3.76 | 1.99 × 10−6 | 0.00029 | 0.06 | −94.21 | ||
| COL11A1 | A | −1.84 | 5.89 | 0.00012 | 0.0065 | 0.28 | −72.07 | ECM modulating/related |
| B | −2.17 | 5.73 | 2.21 × 10−5 | 0.002 | 0.22 | −77.78 | ||
| WNT5A | A | −1.53 | 5.66 | 1.28 × 10−5 | 0.0014 | 0.35 | −65.37 | EMT/MET/WNT |
| B | −1.97 | 5.41 | 0.00022 | 0.0098 | 0.26 | −74.47 | ||
| FLNC | A | −1.33 | 5.90 | 9.01 × 10−5 | 0.0065 | 0.40 | −60.22 | ECM modulating/related |
| B | −1.85 | 5.73 | 5.75 × 10−5 | 0.0042 | 0.28 | −72.26 | ||
| WNT2B | A | −1.17 | 3.93 | 0.00022 | 0.011 | 0.44 | −55.56 | EMT/MET/WNT |
| B | −1.24 | 3.61 | 7.2 × 10−5 | 0.0046 | 0.42 | −57.66 | ||
| CACNA1H | A | −1.05 | 5.80 | 0.00011 | 0.0065 | 0.48 | −51.70 | ER stress, inh. of proliferation |
| B | −1.32 | 5.66 | 0.0013 | 0.038 | 0.40 | −59.95 | ||
| FZD8 | A | −0.98 | 4.53 | 0.00071 | 0.031 | 0.51 | −49.30 | EMT/MET/WNT |
| B | −1.62 | 4.30 | 0.00022 | 0.0098 | 0.33 | −67.47 | ||
| FGF7 | B | −1.65 | 4.00 | 0.00067 | 0.025 | 0.32 | −68.14 | ECM modulating/related |
| COL1A1 | B | −1.07 | 11.31 | 0.00093 | 0.032 | 0.48 | −52.37 | ECM modulating/related |
| COL1A2 | B | −1.04 | 8.57 | 0.0017 | 0.047 | 0.49 | −51.37 | ECM modulating/related |
| LIF | B | −0.75 | 6.01 | 0.0013 | 0.038 | 0.59 | −40.54 | NOTCH inihibition |
| IL1RAP | A | 0.61 | 4.78 | 0.0012 | 0.042 | 1.53 | 52.63 | Oncogenic signaling |
| BNIP3 | B | 1.41 | 5.32 | 0.00038 | 0.015 | 2.66 | 165.74 | ER stress, apoptosis, autophagy |
| NGFR | A | 1.45 | 4.98 | 0.0012 | 0.042 | 2.73 | 173.21 | Ambivalent, tumor suppressor CRC |
| PCK1 | A | 1.6 | 4.37 | 0.00092 | 0.037 | 3.03 | 203.14 | NOTCH, metabolism |
| SPP1/OPN | B | 1.76 | 9.70 | 0.00021 | 0.0098 | 3.39 | 238.70 | EMT/MET/WNT |
| CREB3L3 | A | 2.16 | 2.13 | 3.33 × 10−8 | 1.48 × 10−5 | 4.47 | 346.91 | ER stress, transcription factor |
| B | 2.78 | 2.54 | 5.23 × 10−10 | 2.32 × 10−7 | 6.87 | 586.85 |
Avg expr, average expression (log2); ECM, extracellular matrix; EMT, epithelial to mesenchymal transition; ER, endoplasmic reticulum; FC, fold change; MET, mesenchymal to epithelial transition. Padj, adjusted p value. Genes found in DEG A and B are highlighted in bold.