Figure 1.

Illustration of the 3D in-vivo model for the study of pancreatic ductal adenocarcinoma (1: tumor, 2: CAM-vessels, 3: eggshell, 4: CAM). Cultivation of pancreatic cancer cell lines, as well as tumor biopsies of pancreatic ductal adenocarcinoma patients, can be prepared and grafted onto the CAM model. After a certain cultivation time with the possibility to test potential therapeutics one can assess different aspects of the tumor development. These aspects include histology, tumor angiogenesis, and tumor volume among many other possibly interesting readouts of tumor development.