Table 1.
The best-characterized RNA-binding proteins involved in adipogenesis.
RBP | RNA-Binding Domain | Target Cis-Elements | RNA Targets | Effect on RNA Targets |
---|---|---|---|---|
HuR | RRMs | AU-rich element | Insig1, ATGL | Stabilization |
PSPC1 | RRMs | AU-rich element | Ebf1, PPARγ, Acsl1, and Scd1 | Nuclear export |
Sam68 | KH | U(U/A)AA | mTOR, Rps6kb1 | Alternative splicing |
RBM4 | RRMs, ZF | CU-rich element | PPARγ, Pref1, MEF2C, Prdm16 | Alternative splicing |
Ybx1 | CSD, C-terminal domain | Not determined | Pink1, Prkn | Stabilization |
Ybx2 | CSD, C-terminal domain | Not determined | Pgc1α | Stabilization |
IGF2BP2 | RRM, KH | Not determined | UCP1 | Inhibit translation |
KSRP | KH | AU-rich element | pri-miR-145, pri-miR-150 | miRNA processing |
Abbreviations: RBP: RNA-binding protein; RRM: RNA recognition motif; ZF: zinc finger domain; CSD: cold-shock domain; KH: K homology domain.