Figure 3.

CAFs inhibit T cell migration towards CXCL10. PBMCs were precultured in the absence (black dots) or in the presence of CAFs (light red dots) and activated with OKT3 (25 ng/mL) for 5 days. (Left) Number of migrated CD4⁺ and CD8⁺ T cells towards CXCL10 (20 ng/mL) and CXCL12 (20 ng/mL) relative to medium control. (Right) Schematic representation of the transwell migration assay. Wilcoxon signed-rank test was used to detect statistically significant differences between paired samples. * p  <  0.05, ** p  <  0.01.