Table 1.

Study eligibility criteria.

	Inclusion Criteria	Exclusion Criteria
Participant(s)	Human participants Cancer cohort	Non-human models Non-cancer studies
Intervention(s)	Imaging features investigated (conventional radiomics, semi-quantitative, or semantic features) Performed on radiological images (CT, MRI, and PET)	Studies not focusing on imaging features or radiomics Not performed on radiological datasets
Comparator(s)	CD8 marker interrogated in isolation or in combination with other markers CD8 expression measured, at least, within the tumour (e.g., via immunohistochemistry)	CD8 marker not explicitly interrogated CD8 expression not assessed within the tumour
Outcome(s)	Potential association of one or more imaging features (radiomic signatures) with CD8+ TILs Correlation, discrimination, or performance statistics reported (e.g., area under the curve (AUC) values) Clinically-measurable end point (e.g., survival or ICI response)	Technical studies not focused on deriving radiomic signatures
Study design	Primary sources	Review articles and other secondary sources Conference abstracts and proceedings Inaccessible studies Articles not written in the English language