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. 2022 Jul 28;13:862757. doi: 10.3389/fimmu.2022.862757

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Copyright © 2022 Mostböck, Wu, Fenn, Riegler, Strahlhofer, Huang, Hansen, Kroe-Barrett, Tirapu and Vogt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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anti-VISTA antibodies enhance ongoing immune responses (MLR). PBMCs of donor pairs (two different donors) were co-cultured to induce a mixed leukocyte reaction (MLR) and treated with anti-VISTA-antibodies on IgG4-Pro backbone. (A) TNF levels in MLR culture supernatant treated with three different antibody clones (J014, E008, VSTB112; IgG4-Pro). Data is combined from multiple experiments, thus not showing the same number of data points for all antibody clones. Each connected symbol is a separate donor pair, some of which were used for testing multiple clones. Mean fold-changes between antibodies and respective isotype controls are indicated. (B) Panel of cytokines and chemokines in MLR cultures treated with anti-VISTA-antibody J014-IgG4-Pro. Data is from one experiment, each connected symbol represents a donor pair. * indicates p < 0.05.