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The biophysical characterization of anti-VISTA-antibodies on IgG4-Pro backbone.
| Clone | J014 | E008 | VSTB112 |
|---|---|---|---|
| KD to human VISTA (nM) | >100 | 1.1 | 0.90 |
| KD to cynomologus VISTA (nM) | 44 | 1.0 | 1.1 |
| KD to mouse VISTA (nM) | No binding at 100 nM | ||
| Non-specific binding | No binding to either positively or negatively charged surfaces | ||
| HDX protection | main: 22-36, | main: 22-36, | main: 22-36, |
| (VISTA ECD positions) | 115-134 | 115-134 | 115-134, |
| weak: 37-50 | weak: 37-50 | weak: 37-50 | |
