Table 3.
Genetic association between the SCN polymorphisms and epilepsy.
| Gene | SNP ID | Allelic and Genotypic Frequencies in Cases and Controls |
|||
|---|---|---|---|---|---|
| Allele/ Genotype | Cases (n = 296) |
Controls (n = 293) |
p value* | ||
| SCN1A | rs3812718 | C | 322 (54%) | 349 (60%) | .06 |
| T | 270 (46%) | 235 (40%) | |||
| C/C | 96 (32.9%) | 89 (30.1%) | .039 | ||
| C/T | 157 (53.8%) | 144 (48.6%) | |||
| T/T | 39 (13.4%) | 63 (21.3%) | |||
| rs2298771 | T | 319 (54%) | 297 (51%) | .27 | |
| C | 271 (46%) | 287 (49%) | |||
| T/T | 90 (30.5%) | 76 (26%) | .48 | ||
| C/T | 139 (47.1%) | 145 (49.7%) | |||
| C/C | 66 (22.4%) | 71 (24.3%) | |||
| rs10167228 | A | 319 (54%) | 294 (51%) | .25 | |
| T | 2714 6 (%) | 286 (49%) | |||
| A/A | 90 (30.5%) | 75 (25.9%) | .45 | ||
| A/T | 139 (47.1%) | 144 (49.7%) | |||
| T/T | 66 (22.4%) | 71 (24.5%) | |||
| rs6432858 | T | 320 (54%) | 295 (51%) | .25 | |
| C | 272 (46%) | 287 (49%) | |||
| T/T | 90 (30.4%) | 75 (25.8%) | .45 | ||
| T/C | 140 (47.3%) | 145 (49.8%) | |||
| C/C | 66 (22.3%) | 71 (24.4%) | |||
| rs10194956 | G | 318 (54%) | 334 (60%) | .06 | |
| A | 266 (46% | 224 (40%) | |||
| G/G | 88 (30.1%) | 92 (33%) | .041 | ||
| A/G | 142 (48.6%) | 150 (53.8%) | |||
| A/A | 62 (21.2%) | 37 (13.3%) | |||
| rs2169312 | T | 473 (83%) | 478 (82% | .70 | |
| C | 97 (17%) | 104 (18%) | |||
| T/T | 197 (69.1%) | 195 (67%) | .78 | ||
| T/C | 79 (27.7%) | 88 (30.2%) | |||
| C/C | 9 (3.2%) | 8 (2.8%) | |||
| rs1461197 | G | 390 (67%) | 372 (64%) | .27 | |
| A | 192 (33%) | 210 (36%) | |||
| G/G | 137 (47.1%) | 126 (43.3%) | .57 | ||
| G/A | 116 (39.9%) | 120 (41.2%) | |||
| A/A | 38 (13.1%) | 45 (15.5%) | |||
| rs13405797 | G | 490 (83%) | 486 (83%) | .84 | |
| A | 102 (17%) | 98 (17%) | |||
| G/G | 202 (68.2%) | 200 (68.5%) | .87 | ||
| G/A | 86 (29.1%) | 86 (29.4%) | |||
| A/A | 8 (2.7%) | 6 (2%) | |||
| rs4667866 | A | 560 (95%) | 550 (94%) | .76 | |
| G | 32 (0.05%) | 1834 (0.06%) | |||
| A/A | 265 (89.5%) | 258 (88.4%) | .43 | ||
| A/G | 30 (10.1%) | 34 (11.6%) | |||
| G/G | 1 (0.3%) | 0 (0%) | |||
| rs1020853 | G | 459 (78%) | 455 (78%) | .95 | |
| T | 129 (22%) | 129 (22%) | |||
| G/G | 179 (60.9%) | 178 (61%) | .98 | ||
| G/T | 101 (34.4%) | 99 (33.9%) | |||
| T/T | 14 (4.8%) | 15 (5.1%) | |||
| rs1381105 | T | 448 (76%) | 436 (75%) | .54 | |
| G | 140 (24%) | 148 (25%) | |||
| T/T | 173 (58.8%) | 165 (56.5%) | .84 | ||
| G/T | 102 (34.7%) | 106 (36.3%) | |||
| G/G | 19 (6.5%) | 21 (7.2%) | |||
| rs2162600 | T | 487 (82%) | 479 (82%) | .91 | |
| C | 105 (18%) | 105 (18%) | |||
| T/T | 202 (68.2%) | 195 (66.8%) | .68 | ||
| T/C | 83 (28%) | 89 (30.5%) | |||
| C/C | 11 (3.7%) | 8 (2.7%) | |||
| rs10182473 | T | 457 (78%) | 451 (78%) | N/A | |
| C | 131 (22%) | 129 (22%) | |||
| T/T | 177 (60.2%) | 176 (60.7%) | .96 | ||
| C/T | 103 (35%) | 99 (34.1%) | |||
| C/C | 14 (4.8%) | 15 (5.2%) | |||
| rs16851381 | A | 560 (95%) | 549 (94%) | .84 | |
| G | 32 (0.05%) | 33 (6%) | |||
| A/A | 265 (89.5%) | 258 (88.7%) | .45 | ||
| A/G | 30 (10.1%) | 33 (11.3%) | |||
| G/G | 1 (0.3%) | 0 (0%) | |||
| rs4667869 | C | 483 (82%) | 481 (83%) | .82 | |
| G | 105 (18%) | 101 (17%) | |||
| C/C | 200 (68%) | 197 (67.7%) | .61 | ||
| G/C | 83 (28.2%) | 87 (29.9%) | |||
| G/G | 11 (3.7%) | 7 (2.4%) | |||
| rs10497275 | A | 560 (95%) | 551 (94%) | .85 | |
| G | 32 (0.05%) | 33 (.06%) | |||
| A/A | 265 (89.5%) | 259 (88.7%) | .46 | ||
| G/A | 30 (10.1%) | 33 (11.3%) | |||
| G/G | 1 (0.3%) | 0 (0%) | |||
| rs6432861 | C | 303 (55%) | 343 (60%) | .11 | |
| T | 243 (45%) | 227 (40%) | |||
| C/C | 92 (33.7%) | 97 (34%) | .014 | ||
| T/C | 119 (43.6%) | 149 (52.3%) | |||
| T/T | 62 (22.7%) | 39 (13.7%) | |||
| rs7580482 | C | 306 (52%) | 284 (49%) | .32 | |
| T | 284 (48%) | 296 (51%) | |||
| C/C | 81 (27.5%) | 66 (22.8%) | .42 | ||
| C/T | 144 (48.8%) | 152 (52.4%) | |||
| T/T | 70 (23.7%) | 72 (24.8%) | |||
| rs13383628 | T | 320 (54%) | 347 (60%) | .07 | |
| C | 268 (46%) | 235 (40%) | |||
| T/T | 89 (30.3%) | 95 (32.6%) | .036 | ||
| T/C | 142 (48.3%) | 157 (54%) | |||
| C/C | 63 (21.4%) | 39 (13.4%) | |||
| rs6722462 | T | 394 (67%) | 372 (64%) | .30 | |
| C | 198 (33%) | 212 (36%) | |||
| T/T | 138 (46.6%) | 125 (42.8%) | .61 | ||
| T/C | 118 (39.9%) | 122 (41.8%) | |||
| C/C | 40 (13.5%) | 45 (15.4%) | |||
| rs6432860 | G | 319 (54%) | 295 (51%) | .27 | |
| A | 273 (46%) | 287 (49%) | |||
| G/G | 90 (30.4%) | 75 (25.8%) | .46 | ||
| G/A | 139 (47%) | 145 (49.8%) | |||
| A/A | 67 (22.6%) | 71 (24.4%) | |||
| rs994399 | A | 306 (52%) | 285 (49%) | .32 | |
| G | 284 (48%) | 297 (51%) | |||
| A/A | 81 (27.5%) | 66 (22.7%) | .41 | ||
| A/G | 144 (48.8%) | 153 (52.6%) | |||
| G/G | 70 (23.7%) | 72 (24.7%) | |||
| rs1542484 | A | 315 (54%) | 348 (60%) | .05 | |
| G | 265 (46%) | 232 (40%) | |||
| A/A | 87 (30%) | 96 (33.1%) | .03 | ||
| G/A | 141 (48.6%) | 156 (53.8%) | |||
| G/G | 62 (21.4%) | 38 (13.1%) | |||
| rs1461193 | A | 320 (54%) | 297 (51%) | .27 | |
| G | 272 (46%) | 287 (49) | |||
| A/A | 90 (30.4%) | 76 (26%) | .49 | ||
| G/A | 140 (47.3%) | 145 (49.7%) | |||
| G/G | 66 (22.3%) | 71 (24.3%) | |||
| rs11690959 | G | 321 (55%) | 345 (60%) | .08 | |
| A | 267 (45%) | 233 (40% | |||
| G/G | 89 (30.3%) | 95 (32.9%) | .05 | ||
| A/G | 143 (48.6%) | 155 (53.6%) | |||
| A/A | 62 (21.1%) | 39 (13.5%) | |||
| rs7601520 | A | 310 (55%) | 291 (51%) | .19 | |
| G | 258 (45%) | 283 (49%) | |||
| A/A | 88 (31%) | 75 (26.1%) | .40 | ||
| G/A | 134 (47.2%) | 141 (49.1%) | |||
| G/G | 62 (21.8%) | 71 (24.7%) | |||
| SCN2A | rs12467383 | G | 554 (94%) | 544 (93%) | .60 |
| A | 36 (0.06%) | 40 ( (0.07%) | |||
| G/G | 260 (88.1%) | 253 (86.6%) | .86 | ||
| G/A | 34 (11.5%) | 38 (13%) | |||
| A/A | 1 (0.3%) | 1 (0.3%) | |||
| rs1965757 | A | 419 (71%) | 397 (68%) | .39 | |
| G | 173 (29%) | 183 (32%) | |||
| A/A | 143 (48.3%) | 134 (46.2%) | .51 | ||
| G/A | 133 (44.9%) | 129 (44.5%) | |||
| G/G | 20 (6.8%) | 27 (9.3%) | |||
| rs353139 | T | 365 (64%) | 356 (62%) | .31 | |
| C | 201 (36%) | 222 (38%) | |||
| T/T | 122 (43.1%) | 110 (38.1%) | .46 | ||
| T/C | 121 (42.8%) | 136 (47.1%) | |||
| C/C | 40 (14.1%) | 43 (14.9%) | |||
| rs7581811 | G | 380 (64%) | 352 (61%) | .22 | |
| C | 212 (36%) | 228 (39%) | |||
| G/G | 123 (41.5%) | 106 (36.5%) | .44 | ||
| C/G | 134 (45.3%) | 140 (48.3%) | |||
| C/C | 39 (13.2%) | 44 (15.2%) | |||
| rs2116658 | C | 365 (62%) | 344 (59%) | .24 | |
| T | 219 (38%) | 238 (41%) | |||
| C/C | 121 (41.4%) | 106 (36.4%) | .46 | ||
| C/T | 123 (42.1%) | 132 (45.4%) | |||
| T/T | 48 (16.4%) | 53 (18.2%) | |||
| rs12993173 | T | 367 (63%) | 349 (60%) | .28 | |
| G | 213 (37%) | 231 (40%) | |||
| T/T | 119 (41%) | 105 (36.2%) | .49 | ||
| G/T | 129 (44.5%) | 139 (47.9%) | |||
| G/G | 42 (14.5%) | 46 (15.9%) | |||
| rs4667485 | G | 424 (72%) | 470 (80%) | 4e-4 | |
| C | 168 (28%) | 114 (20%) | |||
| G/G | 151 (51%) | 187 (64%) | 1e-3 | ||
| C/G | 122 (41.2%) | 96 (32.9%) | |||
| C/C | 23 (7.8%) | 9 (3.1%) | |||
| rs1469649 | A | 412 (71%) | 461 (79%) | 1e-3 | |
| G | 168 (29%) | 121 (21%) | |||
| A/A | 145 (50%) | 182 (62.5%) | 5e-3 | ||
| A/G | 122 (42.1%) | 97 (33.3%) | |||
| G/G | 23 (7.9%) | 12 (4.1%) | |||
| rs1579865 | G | 370 (63%) | 330 (58%) | .08 | |
| A | 214 (37%) | 236 (42%) | |||
| G/G | 123 (42.1%) | 99 (35%) | .2 | ||
| G/A | 124 (42.5%) | 132 (46.6%) | |||
| A/A | 45 (15.4%) | 52 (18.4%) | |||
| rs935403 | T | 392 (66%) | 360 (62%) | .18 | |
| C | 200 (34%) | 216 (38%) | |||
| T/T | 125 (42.2%) | 111 (38.5%) | .32 | ||
| T/C | 142 (48%) | 138 (47.9%) | |||
| C/C | 29 (9.8%) | 39 (13.5%) | |||
| rs7592445 | T | 419 (71%) | 398 (69%) | .33 | |
| C | 169 (29%) | 182 (31%) | |||
| T/T | 145 (49.3%) | 135 (46.5%) | .5 | ||
| C/T | 129 (43.9%) | 128 (44.1%) | |||
| C/C | 20 (6.8%) | 27 (9.3%) | |||
| rs2119067 | T | 487 (82%) | 491 (84%) | .41 | |
| C | 105 (18%) | 93 (16%) | |||
| T/T | 200 (67.6%) | 205 (70.2%) | .65 | ||
| C/T | 87 (29.4%) | 81 (27.7%) | |||
| C/C | 9 (3%) | 6 (2%) | |||
| rs2119068 | G | 345 (58%) | 333 (57%) | .71 | |
| C | 245 (42%) | 247 (43%) | |||
| G/G | 100 (33.9%) | 95 (32.8%) | .93 | ||
| C/G | 145 (49.1%) | 143 (49.3%) | |||
| C/C | 50 (16.9%) | 52 (17.9%) | |||
| rs10197716 | A | 420 (73%) | 395 (73%) | .94 | |
| G | 158 (27%) | 147 (27%) | |||
| A/A | 156 (54%) | 149 (55%) | .92 | ||
| G/A | 108 (37.4%) | 97 (35.8%) | |||
| G/G | 25 (8.7%) | 25 (9.2%) | |||
| rs353112 | G | 323 (55%) | 325 (56%) | .57 | |
| C | 269 (45%) | 253 (44%) | |||
| G/G | 95 (32.1%) | 95 (32.9%) | .75 | ||
| G/C | 133 (44.9%) | 135 (46.7%) | |||
| C/C | 68 (23%) | 59 (20.4%) | |||
| rs6740895 | T | 454 (77%) | 431 (74%) | .25 | |
| C | 138 (23%) | 153 (26%) | |||
| T/T | 179 (60.5%) | 162 (55.5%) | .47 | ||
| C/T | 96 (32.4%) | 107 (36.6%) | |||
| C/C | 21 (7.1%) | 23 (7.9%) | |||
| rs3943809 | A | 553 (94%) | 544 (93%) | .69 | |
| G | 37 (0.06%) | 40 (0.07%) | |||
| A/A | 259 (87.8%) | 253 (86.6%) | .91 | ||
| G/A | 35 (11.9%) | 38 (13%) | |||
| G/G | 1 (0.3%) | 1 (0.3%) | |||
| rs16850331 | C | 551 (93%) | 539 (92%) | .47 | |
| T | 39 (0.07%) | 45 (0.08%) | |||
| C/C | 258 (87.5%) | 248 (84.9%) | .51 | ||
| T/C | 35 (11.9%) | 43 (14.7%) | |||
| T/T | 2 (0.7%) | 1 (0.3%) | |||
| rs12614399 | G | 552 (93%) | 538 (0.92%) | .46 | |
| C | 40 (0.07%) | 46 (0.08%) | |||
| G/G | 258 (87.2%) | 247 (84.6%) | .51 | ||
| C/G | 36 (12.2%) | 44 (15.1%) | |||
| C/C | 2 (0.7%) | 1 (0.3%) | |||
| rs10182570 | A | 438 (74%) | 427 (73%) | .73 | |
| C | 152 (26%) | 155 (27%) | |||
| A/A | 165 (55.9%) | 161 (55.3%) | .88 | ||
| C/A | 108 (36.6%) | 105 (36.1%) | |||
| C/C | 22 (7.5%) | 25 (8.6%) | |||
| rs1446579 | G | 316 (54%) | 301 (52%) | .45 | |
| A | 268 (46%) | 279 (48%) | |||
| G/G | 89 (30.5%) | 75 (25.9%) | .41 | ||
| G/A | 138 (47.3%) | 151 (52.1%) | |||
| A/A | 65 (22.3%) | 64 (22.1%) | |||
| SCN3A | rs7598098 | G | 447 (78%) | 428 (74%) | .15 |
| C | 127 (22%) | 148 (26%) | |||
| G/G | 176 (61.3%) | 162 (56.2%) | .38 | ||
| C/G | 95 (33.1%) | 104 (36.1%) | |||
| C/C | 16 (5.6%) | 22 (7.6%) | |||
| rs12615864 | G | 544 (93%) | 531 (91%) | .16 | |
| A | 40 (0.07%) | 53 (0.09%) | |||
| G/G | 255 (87.3%) | 242 (82.9%) | .30 | ||
| A/G | 34 (11.6%) | 47 (16.1%) | |||
| A/A | 3 (1%) | 3 (1%) | |||
| rs16850186 | G | 535 (90%) | 502 (86%) | .03 | |
| A | 57 (10%) | 80 (14%) | |||
| G/G | 243 (82.1%) | 219 (75.3%) | .1 | ||
| A/G | 49 (16.6%) | 64 (22%) | |||
| A/A | 4 (1.4%) | 8 (2.8%) | |||
| rs1439806 | G | 422 (74%) | 441 (77%) | .22 | |
| A | 146 (26%) | 129 (23%) | |||
| G/G | 160 (56.3%) | 166 (58.2%) | .08 | ||
| G/A | 102 (35.9%) | 109 (38.2%) | |||
| A/A | 22 (7.8%) | 10 (3.5%) | |||
| rs7596422 | A | 296 (50%) | 299 (52%) | .64 | |
| G | 294 (50%) | 281 (48%) | |||
| A/A | 77 (26.1%) | 78 (26.9%) | .86 | ||
| G/A | 142 (48.1%) | 143 (49.3%) | |||
| G/G | 76 (25.8%) | 69 (23.8%) | |||
| SCN1B | rs72550243 | C | 592 (100%) | 581 (99%) | .08 |
| T | 0 (0%) | 3 (0.01%) | |||
| C/C | 296 (100%) | 289 (99%) | .04 | ||
| C/T | 0 (0%) | 3 (1%) | |||
| SCN2B | rs8192613 | G | 366 (62%) | 351 (60%) | .54 |
| T | 226 (38%) | 233 (40%) | |||
| G/G | 114 (38.5%) | 110 (37.7%) | .69 | ||
| G/T | 138 (46.6%) | 131 (44.9%) | |||
| T/T | 44 (14.9%) | 51 (17.5%) | |||
| rs8192614 | G | 516 (87%) | 506 (87%) | .96 | |
| A | 76 (13%) | 74 (13%) | |||
| G/G | 225 (76%) | 224 (77.2%) | .56 | ||
| G/A | 66 (22.3%) | 58 (20%) | |||
| A/A | 5 (1.7%) | 8 (2.8%) | |||
| SCN3B | rs3851100 | T | 534 (93%) | 541 (93%) | .87 |
| C | 42 (0.07%) | 41 (0.07%) | |||
| T/T | 249 (86.5%) | 252 (86.6%) | .9 | ||
| T/C | 36 (12.5%) | 37 (12.7%) | |||
| C/C | 3 (1%) | 2 (0.7%) | |||
| rs1783901 | C | 426 (72%) | 442 (76%) | .12 | |
| T | 166 (28%) | 140 (24%) | |||
| C/C | 158 (53.4%) | 171 (58.8%) | .32 | ||
| C/T | 110 (37.2%) | 100 (34.4%) | |||
| T/T | 28 (9.5%) | 20 (6.9%) | |||
| SCN8A | rs303777 | G | 424 (73%) | 433 (75%) | .42 |
| A | 158 (27%) | 145 (25%) | |||
| G/G | 160 (55%) | 163 (56.4%) | .48 | ||
| G/A | 104 (35.7%) | 107 (37%) | |||
| A/A | 27 (9.3%) | 19 (6.6%) | |||
| rs11169883 | C | 351 (59%) | 312 (54%) | .05 | |
| T | 241 (41%) | 270 (46%) | |||
| C/C | 112 (37.8%) | 89 (30.6%) | .15 | ||
| T/C | 127 (42.9%) | 134 (46%) | |||
| T/T | 57 (19.3%) | 68 (23.4%) | |||
| rs303778 | A | 503 (85%) | 509 (87%) | .28 | |
| G | 89 (15%) | 75 (13%) | |||
| A/A | 213 (72%) | 221 (75.7%) | .54 | ||
| A/G | 77 (26%) | 67 (22.9%) | |||
| G/G | 6 (2%) | 4 (1.4%) | |||
*p value <0.025 was considered as significant after performing Bonferroni correction.