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. 2022 Jul 8;54(1):1938–1951. doi: 10.1080/07853890.2022.2096257

Table 5.

Regression analysis of SCN variants and epilepsy features.

Gene SNP ID gender relapse History of febrile seizure periodic Seizure Time to remission Drug responsiveness drug level Family history of epilepsy Epilepsy classification Seizure classification
SCN1A rs3812718 0.060 0.054 0.375 0.268 0.588 0.820 0.382 0.645 0.458 0.976
rs2298771 0.398 0.118 0.781 0.268 0.632 0.914 0.987 0.552 0.220 0.685
rs10167228 0.124 0.322 0.670 0.489 0.347 0.947 0.053 0.426 0.436 0.661
rs6432858 0.430 0.104 0.797 0.281 0.585 0.882 0.975 0.609 0.216 0.695
rs10194956 0.189 0.272 0.156 0.618 0.771 0.248 0.018 0.491 0.953 0.477
rs2169312 0.084 0.156 0.006 0.660 0.383 0.098 0.310 0.067 0.669 0.859
rs1461197 0.137 0.549 0.203 0.062 0.088 0.664 0.155 0.206 0.337 0.101
rs13405797 0.105 0.257 0.023 0.734 0.772 0.068 0.289 0.035 0.635 0.731
rs4667866 0.896 0.324 0.988 0.497 0.317 0.454 0.599 0.910 0.759 0.218
rs1020853 0.098 0.523 0.667 0.197 0.704 0.347 0.718 0.431 0.185 0.980
rs1381105 0.054 0.376 0.051 0.346 0.136 0.348 0.518 0.035 0.521 0.378
rs2162600 0.088 0.436 0.026 0.720 0.501 0.116 0.308 0.065 0.656 0.841
rs10182473 0.099 0.500 0.167 0.530 0.073 0.228 0.247 0.114 0.359 0.769
rs16851381 0.896 0.324 0.988 0.497 0.317 0.454 0.599 0.910 0.759 0.218
rs4667869 0.082 0.490 0.238 0.378 0.428 0.195 0.704 0.344 0.509 0.779
rs10497275 0.896 0.324 0.988 0.497 0.317 0.454 0.599 0.910 0.759 0.218
rs6432861 0.388 0.055 0.208 0.431 0.742 0.898 0.415 0.588 0.561 0.993
rs7580482 0.173 0.587 0.484 0.905 0.445 0.970 0.053 0.466 0.430 0.693
rs13383628 0.228 0.215 0.155 0.728 0.823 0.262 0.040 0.574 0.958 0.471
rs6722462 0.256 0.585 0.191 0.068 0.075 0.807 0.147 0.466 0.325 0.096
rs6432860 0.391 0.091 0.777 0.264 0.587 0.921 0.990 0.644 0.170 0.682
rs994399 0.191 0.546 0.472 0.882 0.408 0.939 0.051 0.517 0.424 0.703
rs1542484 0.382 0.062 0.591 0.268 0.713 0.671 0.628 0.586 0.457 0.974
rs1461193 0.139 0.293 0.655 0.508 0.314 0.979 0.051 0.476 0.430 0.671
rs11690959 0.212 0.197 0.148 0.654 0.781 0.284 0.039 0.541 0.948 0.482
rs7601520 0.193 0.456 0.930 0.649 0.447 0.904 0.050 0.639 0.550 0.666
SCN2A rs12467383 0.096 0.253 0.876 0.716 0.980 0.069 0.167 0.922 0.298 0.317
rs1965757 0.022 0.690 0.072 0.733 0.347 0.334 0.670 0.762 0.708 0.090
rs353139 0.099 0.104 0.040 0.814 0.787 0.047 0.395 0.368 0.680 0.419
rs7581811 0.035 0.115 0.586 0.711 0.906 0.262 0.919 0.872 0.767 0.517
rs2116658 0.642 0.542 0.500 0.542 0.939 0.553 0.690 0.267 0.502 0.165
rs12993173 0.082 0.248 0.370 0.643 0.909 0.584 0.831 0.531 0.882 0.602
rs4667485 0.167 0.875 0.609 0.011 0.815 1.00 0.695 0.319 0.555 0.994
rs1469649 0.257 0.841 0.679 0.040 0.911 0.774 0.594 0.743 0.228 0.782
rs1579865 0.407 0.559 0.492 0.769 0.989 0.300 0.452 0.097 0.547 0.131
rs935403 0.197 0.666 0.131 0.337 0.461 0.271 0.946 0.897 0.853 0.014
rs7592445 0.021 0.717 0.052 0.720 0.624 0.430 0.574 0.793 0.848 0.102
rs2119067 0.540 0.367 0.050 0.753 0.712 0.349 0.515 0.023 0.062 0.975
rs2119068 0.266 0.059 0.132 0.209 0.452 0.519 0.941 0.692 0.294 0.918
rs10197716 0.489 0.656 0.226 0.055 0.928 0.986 0.536 0.070 0.070 0.422
rs353112 0.851 0.980 0.271 0.006 0.279 0.354 0.203 0.769 0.851 0.209
rs6740895 0.374 0.945 0.986 0.614 0.650 0.148 0.276 0.478 0.821 0.840
rs3943809 0.044 0.426 0.828 0.716 0.984 0.067 0.325 0.898 0.297 0.320
rs16850331 0.066 0.347 0.783 0.583 0.947 0.042 0.151 0.802 0.174 0.813
rs12614399 0.049 0.452 0.485 0.580 0.980 0.034 0.181 0.641 0.170 0.844
rs10182570 0.712 0.954 0.782 0.001 0.711 0.455 0.378 0.833 0.039 0.578
rs1446579 0.427 0.518 0.268 0.310 0.334 0.260 0.808 0.757 0.525 0.371
SCN3A rs7598098 0.024 0.277 0.980 0.350 0.751 0.972 0.571 0.194 0.923 0.235
rs12615864 0.662 0.740 0.935 0.538 0.798 0.862 0.292 0.118 0.418 0.260
rs16850186 0.636 0.382 0.489 0.716 0.847 0.535 0.706 0.848 0.165 0.154
rs1439806 0.622 0.900 0.726 0.277 0.190 0.544 0.115 0.821 0.971 0.895
rs7596422 0.090 0.567 0.088 0.602 0.564 0.169 0.011 0.474 0.651 0.753
SCN2B rs8192613 0.798 0.125 0.730 0.465 0.367 0.963 0.464 0.135 0.655 0.864
rs8192614 0.626 0.612 0.150 0.257 0.438 0.291 0.415 0.660 0.256 0.551
SCN3B rs3851100 0.387 0.427 0.148 0.578 0.603 0.997 0.474 0.289 0.232 0.312
rs1783901 0.246 0.754 0.999 0.114 0.489 0.173 0.929 0.578 0.141 0.073
SCN8A rs303777 0.918 0.645 0.479 0.225 0.245 0.786 0.692 0.764 0.746 0.961
rs11169883 0.393 0.806 0.989 0.623 0.111 0.781 0.019 0.105 0.249 0.058
rs303778 0.381 0.906 0.316 0.019 0.434 0.572 0.705 0.556 0.178 0.329

Linear regression using Pearson's r test.

p value <.05 is significant.