Table 1.
Basic characteristics of the studies included in the meta-analysis (n = 45).
| Study | Year | Patients | Area | ICI type | ATB window | Method | |
|---|---|---|---|---|---|---|---|
| A. Iglesias‐Santamariía (12) | 2019 | 102 | Spain | CTLA-4, PD-1,PD-L1 | (−28,28) | Retrospective cohort study | |
| Akhil Kapoor (13) | 2020 | 155 | India | nivolumab | (−14,14) | Retrospective cohort study, | |
| Aly-Khan A. Lalani (14) | 2019 | 146 | NK | PD-1, PD-L1 | (−56,28) | Retrospective cohort study | |
| Amit A Kulkarni (15) | 2020 | 195 | Caucasian, African, American, Others | Nivolumab Pembrolizumab Others | (−28,42) | Retrospective cohort study | |
| Andrew F. Nyein (16) | 2022 | 256 | American | PD-1, PD-L1, CTLA-4 | (−60,30) | Retrospective cohort study | |
| Angelo Castello (17) | 2021 | 50 | Italy | PD-1,PL-L1 | (−30,30) | RCT | |
| Anne Schett (18) | 2020 | 218 | Switzerland | PD-1,PD-L1 | (−60,30) | Retrospective cohort study | |
| Arielle Elkrief (19) | 2019 | 74 | NK | PD-1, CTLA-4 | (0,30) | Retrospective cohort study | |
| Bertrand Routy (20) | 2022 | 100 | NK | PD-1,PL-L1 | NK | RCT | |
| C hogue (21) | 2019 | 161 | American | PD-1 | (−90,0) | Retrospective cohort study | |
| Coureche Kaderbhai (22) | 2017 | 74 | France | PD-1 | (−90,0) | Retrospective cohort study | |
| David J. Pinato (23) | 2019 | 196 | London | PD-L1 | (−30,0) | RCT | |
| Deniz Can Guve (24) | 2021 | 93 | Turkey | PD-1 | (−90,90) | Retrospective cohort study | |
| F. Barroín (25) | 2019 | 140 | Mexico | PD-L1 | (0,30) | Retrospective cohort study | |
| Florian Huemer (26) | 2019 | 142 | Austria | PD-1, PD-L1 | (−30,30) | Retrospective cohort study | |
| Florian Huemer (27) | 2018 | 30 | Austria | PD-1 | (−30,30) | Retrospective cohort study | |
| Hyunho Kim (28) | 2019 | 234 | Korea | CTLA-4, PD-1,PD-L1 |
(−60,0) | Retrospective cohort study | |
| Jahan J. Mohiuddin (29) | 2020 | 568 | American | PD-1, CTLA-4 |
(−90,90) | Retrospective cohort study | |
| Jhe-cyuan Guo (30) | 2019 | 49 | Taiwan | PD-1, PD-L1 | (−60,30) | Retrospective cohort study | |
| Jibran Ahmed (31) | 2018 | 60 | USA | PD-1,PD-L1 | (−14,14) | Retrospective cohort study | |
| Julia Ouaknine Krief (32) | 2019 | 72 | France | PD-1 | (−60,30) | Retrospective cohort study | |
| Jwa Hoon Kim (33) | 2021 | 53 | Korea | PD-1 | (−30,0) | Retrospective cohort study | |
| Ka Shing Cheung (34) | 2021 | 412 | China | PD-1, CTLA-4 |
(−30,30) | Retrospective cohort study | |
| Katharina Pomej (35) | 2021 | 206 | Vienna | NK | (−30,0) | Retrospective cohort study | |
| Kazuyuki Hamada (36) | 2021 | 69 | Japan | PD-1 | (−21,21) | Retrospective cohort study | |
| Kosuke Ueda (37) | 2019 | 31 | Japan | PD-1, CTLA-4 |
(−30,0) | Retrospective cohort study | |
| L. Derosa (38) | 2018 | 121 | America | PD-L1 | (−60,0) | Retrospective cohort study | |
| Laura M. Chambers (39) | 2021 | 101 | USA | PD-L1 | (−30,0) | Retrospective cohort study, RCT |
|
| Louis Gaucher (40) | 2021 | 372 | France | PD-1, CTLA-4 | (0,60) | Retrospective cohort study | |
| M. Chalabi (41) | 2020 | 1,512 | Netherlands | PD-L1 | (−30,30) | Retrospective cohort study, | |
| Megan Greally (42) | 2019 | 161 | American | PD-1,PD-L1, CTLA-4 |
(−60,0) | NK | |
| Metges (43) | 2018 | 798 | NK | PD-1 | (−60,30),(−60,150) | Retrospective cohort study | |
| Min Jung Geum (44) | 2021 | 140 | NK | PD-1 | NK | Retrospective cohort study | |
| Nadina Tinsley (45) | 2020 | 347 | England | NK | (−14,42) | Retrospective cohort study | |
| Nobuaki Ochi (46) | 2021 | 531 | Japan | PD-L1 | (−60,60) | Retrospective cohort study | |
| Petros Fessas (47) | 2021 | 450 | Europe, North America, Asia |
PD-1,PD-L1 | (−30,0)(0,30)(−30,30) | Retrospective cohort study | |
| Pierre-Yves Cren (48) | 2020 | 1,585 | France | CTLA-4 | (−60,60) | Retrospective cohort study | |
| Po-Hsien Lu MS (49) | 2020 | 340 | Taiwan | PD-1, PD-L1,CTLA-4 |
(−30,0) | Retrospective cohort study | |
| Quentin (50) | 2021 | 212 | France | PD-1 | (−60,0) | Retrospective cohort study | |
| Sha Zhao (51) | 2019 | 109 | China | PD-1/PD-L1 | (−30,30) | Retrospective cohort study | |
| Steven R. Hwang (52) | 2020 | 62 | USA | PD-1, CTLA-4 | (−90,0)(0,90) | Retrospective cohort study | |
| Taiki Hakozaki (53) | 2020 | 70 | Japan | PD-1/PD-L1 | (−30,0) | RCT | |
| Uqba Khan (9) | 2021 | 414 | American | PD-1,PD-L1, CTLA-4 |
(−84,84) | Retrospective cohort study | |
| X. Mielgo Rubio (54) | NK | 121 | Spanish | PD-1 | (−60,60) | Retrospective cohort study | |
| Ying Jing (55) | 2022 | 767 | china | PD-1, PD-L1 | (−90,90) | Retrospective cohort study | |
NK, not known.