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. 2022 Jul 28;13:919815. doi: 10.3389/fimmu.2022.919815

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Copyright © 2022 Manangeeswaran, Ireland, Thacker, Lee, Kelley-Baker, Lewkowicz, Rothlauf, Cornejo Pontelli, Bloyet, Eckhaus, Mendoza, Whelan and Verthelyi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lung infection in mice challenged with SARS-CoV-2 and rVSV-SARS2-S viruses. (A) Left panels: Immunohistochemistry for Spike RBD. Red arrows indicate SARS-CoV-2 infected cells. Blue arrows indicate rVSV-SAR2-S infected cells. Right panels show H&E staining of lungs (100 and 600X). Green arrows indicate infiltrating immune cells (image representative of 6 mice/group). (B) Fold-change in selected genes from the lungs of SARS-CoV-2 and rVSV-SARS2-S (n=8) infected mice at P8 compared to age-matched uninfected control mice as assessed using Nanostring technology (nCounter Mouse Immunology Panel). The complete gene expression profile can be found in Supplementary Figure 4.