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. 2022 Jul 28;13:962341. doi: 10.3389/fimmu.2022.962341

Figure 4.

Figure 4

GFPA alleviated hepatic steatosis in mice with DIO. In HFD-fed mice, GFPA suppressed the serum concentrations of (A) ALT and (B) AST and the hepatic concentrations of (C) ALT and (D) AST. Data are expressed as means ± S.E.M. (n = 6). # p < 0.05, ## p < 0.01 and ### p < 0.001 versus NCD-fed mice; *p < 0.05 and **p < 0.01 versus HFD-fed mice. Pathological alterations in the liver were evaluated by (E) H&E staining (magnification: 200×; scale bar: 50 μm) and (F) Oil red O staining (magnification: 200×; scale bar: 50 μm). The black arrow indicates the inflammatory infiltration of lymphocytes in HFD-fed mice, and the red arrow indicates ballooning degeneration, cytoplasmic vacuolation and cellular swelling in HFD-fed mice.