PFM regulated the bacterial community of the cecum microbiota. (a) ACE Index; (b) NMDS; (c) PLS-DA on the OTU level between W and LN; (d) relative abundance richness at phyla level; and (e) LEFSE on family level. (f) Correlation heatmap between intestinal microorganisms and environmental factors (serum differential metabolites), * p < 0.05, **p < 0.01, *** p < 0.001. (g) Correlation heatmap between intestinal microorganisms and environmental factors (differential metabolites of cecal contents), * p < 0.05, ** p < 0.01, *** p < 0.001. cont W: animals not treated with L-NAME receiving standard chow; cont LN: L-NAME treated rats receiving standard chow; LN + SR37-3: L-NAME treated rats receiving PFM-SR37-3; LN + SR61-2: L-NAME treated rats receiving PFM-SR61-2.