Table 2.
Comparison of miR-Score Distributions Between Groups with Various Findings at Screening Colonoscopy.
| miR-Score | Comparison CRC–AA |
Comparison AA–NAA |
Comparison NAA–No Neoplasm |
||||
|---|---|---|---|---|---|---|---|
| CRC (n = 52) | AA (n = 100) |
NAA (n = 88) | No neoplasm (n = 173) |
||||
| Mean (SD) | −0.8 (0.7) | −0.6 (0.7) | −0.8 (0.7) | −0.6 (0.7) | |||
| Median (Range) | −0.8 (−2.6–0.7) | −0.5 (−2.4–1.2) | −0.8 (−2.6–0.9) | −0.6 (−3.3–3.0) | |||
| p-Value a | 0.014 | 0.027 | 0.127 | ||||
| miR-Score Category b | OR (95% CI) c | OR (95% CI) c | OR (95% CI) c | ||||
| Low | 24 (46.2) | Ref | 28 (28.0) | Ref | 32 (36.4) | Ref | 58 (33.5) |
| Medium | 15 (28.8) | 0.54 (0.23−1.22) | 32 (32.0) | 1.05 (0.52−2.12) | 35 (39.8) | 1.07 (0.58−1.98) | 57 (32.9) |
| High | 13 (25.0) | 0.37 (0.16−0.86) | 40 (40.0) | 2.22 (1.06−4.64) | 21 (23.9) | 0.63 (0.32−1.24) | 58 (33.5) |
| OR per SD Increase | 0.66 (0.47−0.94) | 1.35 (1.00−1.82) | 0.79 (0.61−1.04) | ||||
| AUC | 0.38 (0.28−0.47) | 0.59 (0.51−0.68) | 0.44 (0.37−0.52) | ||||
| Brier Score | 0.269 | 0.280 | 0.257 |
a Assessed by Mann–Whitney test. b Tertiles of risk score among participants with no colorectal neoplasms (controls). c Adjusted for age and sex. Bold values indicate statistically significant results. Abbreviations: AA, advanced colorectal adenoma; AUC, area under the receiver operating characteristic curve; CI, confidence interval; CRC, colorectal cancer; miR-score, microRNA risk score; n, number; NAA, non-advanced colorectal adenoma; OR, odds ratio; Ref., reference category; SD, standard deviation.