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. 2022 Aug 5;11(15):2421. doi: 10.3390/cells11152421

Figure 2.

Figure 2

MiR-187-3p overexpression inhibited CRC cell migration and colony formation: (A) MiR-187-3p plasmids or control vectors were stably overexpressed in HCT116 or SW480 cells. Quantitative PCR was performed to determine the expression of miR-187-3p in miR-187-3p or control vector clones. (B) Colony-formation assay was performed to compare the clonogenic ability of stable miR-187-3p and control vector HCT116 or SW480 cells. (C) Wound-healing assay was performed to compare the cell migration rates of stable HCT116 or SW480 cells with miR-187-3p or the control vector 48 h after wound creation. (D) Cell migration assay was performed to compare the migration ability of stable HCT116 or SW480 cells with miR-187-3p or the control vector. (E) Cell invasion assay was performed to compare the invasion ability of stable HCT116 or SW480 cells with miR-187-3p or the control vector. All experiments were performed in duplicate, and the data are expressed as the mean ± SEM of three independent experiments; * indicates that the difference is statistically significant (p < 0.05).