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. 2022 Aug 5;11(15):2421. doi: 10.3390/cells11152421

Figure 4.

Figure 4

MiR-187-3p levels were associated with the age and tumor stage of CRC patients: (A) MiR-187-3p levels in paired CRC and adjacent normal tissues of 56 CRC patients in the study cohort. (B) The miR-187-3p levels were significantly lower in patients aged 65 years or above compared to those aged below 65. (C) The miR-187-3p levels were significantly higher in stage II–IV CRCs compared to stage I CRCs. (D) MiR-187-3p levels in paired CRC and adjacent normal tissues of 160 CRC patients in the validation cohort. (E) The miR-187-3p levels were significantly lower in patients aged 65 years or above compared to those aged below 65. (F) The miR-187-3p levels were significantly higher in stage II–IV CRCs compared to stage I CRCs. (G) TCGA analysis showed that miR-187-3p levels were significantly different between different age groups in patients with colon cancer (upper panel) or rectal cancer (lower panel). (H) TCGA analysis showed that miR-187-3p levels were significantly higher or tended to be higher in stage II–IV CRCs compared to stage I CRCs for patients with colon cancer (upper panel) or rectal cancer (lower panel). ∙ and ○ indicated the individual data points of adjacent normal tissues and CRC, respectively.