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Summary of the process that occurs during the tissue-remodeling phase of healing. The release of MMP from fibroblasts, macrophages, and myofibroblasts helps to remodel the ECM by converting type III collagen into type I collagen. Fibrin-based ECM made during the first phase of healing is replaced by collagen-based ECM. The very few cells that remain in the wound are removed by apoptosis and neovascularization ceases. ECM, extracellular matrix; MMP, matrix metalloproteinase.
