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. 2022 Aug 4;11(15):2411. doi: 10.3390/cells11152411

Figure 3.

Figure 3

Denatonium activates Tas2R108 and Tas2R105. (A) Application of denatonium (1 mM) increased [Ca2+]i in HEK293 cells transfected with Tas2R108 (red) or Tas2R105 (green) but not in untransfected HEK293 cells. The ATP (10 µM) control stimulus increased [Ca2+]i in all cell lines. Representative curves for the Ca2+ response. (B) The denatonium-induced [Ca2+]i was increased in the HEK293 cells transfected with Tas2R108 (n = 99) or Tas2R105 (n = 160) compared to untransfected HEK293 cells (n = 227) and the [Ca2+]i response to denatonium was higher in HEK293 Tas2R105 cells than in HEK293 Tas2R108 cells (* p < 0.05).