Table 5.
A representative list of microRNAs (miRs) that are involved in different phases of wound healing.
| Wound Healing Phase | microRNAs (miRs) | Function | Effect on Wound Healing | Reference |
|---|---|---|---|---|
| Inflammation | miR-142-3p/5p | Promotion of neutrophils migration | Promote wound healing | [311] |
| Inflammation | miR-203 | Alleviation of skin inflammation | Promote wound healing | [312] |
| Inflammation | miR-23b | Escalation of of anti-inflammatory cytokines and reduction of pro-inflammatory cytokines | Promote wound healing | [313] |
| Inflammation | miR-27b | Reduce ROS production | Promote wound healing | [314] |
| Inflammation | miR-34 | Enhancement of NF-κB signaling pathway activity | Impede wound healing | [315] |
| Angiogenesis | miR-615-5p | Inhibition of angiogenesis by targeting protein kinase B/endothelial nitric oxide synthase signaling pathway | Impede wound healing | [316] |
| Angiogenesis | miR-21 | Suppression of angiogenesis by downregulating the expression of tensin homolog (PTEN) and SMAD7 genes | Impede wound healing | [317] |
| Angiogenesis | miR-126 | Enhances migration and repair of endothelial cells | Promote wound healing | [318] |
| Angiogenesis | miR-221 and miR-222 |
The expression of endothelial NO |
Impede wound healing | [319] |
| Re-epithelialization | miR-31 | Enhances keratinocytes proliferation and migration | Promote wound healing | [320] |
| Re-epithelialization | miR-21 | Promotes fibroblasts differentiation, collagen synthesis, and re-epithelialization | Promote wound healing | [321] |
| Granulation tissue formation | miR-29b | Inhibits expression of heat shock protein 47 (HSP47) and collagen synthesis |
Impede wound healing | [322] |
| Granulation tissue formation | miR-185 | Inhibits fibroblasts growth and function | Impede wound healing | [323] |