Table 2.

Upstream regulators (overlap P < .0003; activation z score > 2 or < –2) Enriched in 902 proliferative vs mid-secretory differentially expressed genes that are less than 100 kb from a proliferative estrogen receptor α chromatin immunoprecipitation and next-generation sequencing peak

	Regulators
Process	Increased activity	Decreased activity
Chromatin	EP400	NUPR1, SMARCB1, let-7
Cytokine signaling	IL10RA	IFNG, IL1B, IL6
Estrogen	ESR1, E2
Growth factor		FGF1, VEGFB, PDGF BB
Growth factor/RTK	ERBB2
RTK signaling	Insulin, MAPK1
Progesterone		P4, PGR
Proliferation	FOXM1, CKAP2L, RABL6, CCND1, CCND1	CDKN2A, TP53, Rb
Receptor signaling	RARA, AGT	DEX, calcitriol, NR3C1
Transcription	E2f, TBX2, MYC, CEBPB, SOX4	HNF4A, EHMT1

Abbreviations: AGT, angiotensin; CEBPB, CCAAT enhancer binding protein β; CDKN2A, cyclin-dependent kinase inhibitor 2A; CKAP2L, cytoskeleton associated protein 2 like; DEX, dexamethasone; E2, estradiol; EHMT1, euchromatic histone lysine methyltransferase 1; EP400, E1A binding protein p400; ERBB2, Erb-b2 receptor tyrosine kinase 2; ESR1, estrogen receptor α; FGF1, fibroblast growth factor 1; FOXM1, forkhead box M1; HNF4A, hepatocyte nuclear factor 4 α; IFNG, interferon γ; IL1B, interleukin 1B; IL6, interleukin 6; MAPK1, mitogen-activated protein kinase 1; NUPR1, nuclear protein 1, transcriptional regulator; PDGF BB, platelet-derived growth factor BB; PGR, progesterone receptor; RABL6, RAS oncogene family like 6; RARA, retinoic acid receptor a; RTK, receptor tyrosine kinase; SMARCB1, SWI/SNF component SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1; SOX4, SRY-box transcription factor 4; TBX2, T-box transcription factor 2; TP53, tumor protein 53; VEGFB, vascular endothelial growth factor B.