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. 2022 Aug 3;11(15):2392. doi: 10.3390/cells11152392

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A model for HP1-dependent VL30-LTR ERV transcription control at the Trim24 locus. In wild-type liver, the RLTR-86 VL30-LTR is covered by a repressive complex (blue shaded oval) triggered by H3K9me3, H4K20me3 and H3K27me3 repressive marks in the presence of the H3H4me1 enhancer mark. This peculiar epigenetic bookmarking prevents the long-range interaction of this ERV with the Trim24 promoter. Upon loss of HP1 (HP1-TKO), H3K27me3 is specifically decreased leading to the release of the repressive complex and recruitment of specific transcription factors (pale orange oval), thus allowing the association of this ERV with the Trim24 promoter and increasing the expression of this gene.