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. 2022 Jul 28;13:912005. doi: 10.3389/fimmu.2022.912005

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Copyright © 2022 Kölliker Frers, Otero-Losada, Kobiec, Udovin, Aon Bertolino, Herrera and Capani

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inflammation in MS periventricular lesions with paramagnetic rims on 3T MRI. Lesion edge shows paramagnetic substances related to inflammation. (A) Schematic view of the lesion (pink color) in the periventricular area; (B) Active chronic lesion with peripheral gadolinium leak (centripetal pattern) and paramagnetic border (clear zone); (C) Active chronic lesion with paramagnetic border (delimited by dark gray border), observed without contrast. Images (B, C) show periventricular RRMS lesions with paramagnetic edges (postcontrast and precontrast, respectively, in T1 images); L, Lesion; V, Ventricle.