Table 1.

Findings supporting the biomarker value of circulating NFL concentration in MS.

Reference #	Results	Value
(63)	NFL level was higher in patients with either RRMS (16.9 ng/L) or PPMS or SPMS (23 ng/L) than in controls (10.5 ng/L).	diagnostic
(84)	NFL level was associated with gadolinium-binding T1 lesions up to 2 months back and 1 month forth.	prognostic
(6)	NFL fluctuation correlated with EDSS score and neuropsychological outcome variation over 24 months. Brain volume decreased faster in patients with higher baseline NFL levels. The increase in NFL levels predicted the increase in brain lesions.	prognostic
(85)	Baseline NFL levels were associated with the number of gadolinium-binding lesions and the accumulation of new lesions in T2. Patients with a high rate of cerebral atrophy progression had high NFL levels.	disease activity biomarker
(86)	NFL level at the initial stages of the disease correlated with brain lesions detected ten years later, including cerebral parenchymal fraction and volume of hyperintense lesions in T2 sequences.	prognostic
(7)	Over 6.5 years’ follow-up, NFL level above the 90th percentile of control values was an independent predictor of the following year worsening EDSS in MS patients. Lesions were independently associated with increased NFL level. The higher the NFL percentile, the more pronounced were brain and spinal volume losses.	prognostic