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. 2022 Aug 5;11(15):2432. doi: 10.3390/cells11152432

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Summary of the effects of PPARα, PPARβ/δ, and PPARγ on tumor metabolism. ↓ indicates inhibition and ↑ indicates an increase. ⇒: leads to; ANGPTL4: angiopoietin-like 4; ACOX1: acyl-coenzyme A oxidase 1; CPT1A: carnitine palmitoyltransferase 1A; FAO: fatty-acid oxidation; ALDH7A1: aldehyde dehydrogenase 7 family member A1; Glut1: glucose transporter 1; ULCFA: unsaturated long-chain fatty acids; FABP5: fatty-acid-binding protein 5; TRMT6: tRNA methyltransferase 6 non-catalytic subunit; TRMT61A: tRNA methyltransferase 61A; SLC1A5: solute carrier family 1 member 5; USP22: ubiquitin-specific peptidase 22; ACC: acetyl-CoA carboxylase; ACLY: ATP citrate lyase; ACBP: acyl-CoA binding protein; HCC: hepatocellular carcinoma; AKT3: AKT serine/threonine kinase 3; ATP: adenosine triphosphate; ROS: reactive oxygen species; pRB: phosphorylated retinoblastoma protein.