FIGURE 2.

Axial T2 weighted images at baseline (A,B) and at the last follow-up evaluation (C,D) of the untreated patient (case 1). Panels (A,C) are planes crossing through the basal ganglia, while panels (B,D) are planes crossing through the corona radiata. The baseline study identifies capsular degeneration (arrows, A) and periventricular white matter injury with “tigroid appearance” (arrowheads, B) also known as the stripe sign. The tigroid appearance is also present in the white matter of the corona radiata (arrowheads, B). The extra axial spaces are enlarged. The follow-up examination, which is represented in panels (C,D), shows rapid and diffuse deterioration of the neuroimaging findings both at the level of the capsular regions (arrows, C) and periventricular white matter (arrowheads, C,D). The volume loss of the brain parenchyma is not accompanied by a significant increase in caliber of the extra axial spaces.