FIGURE 3.

Axial T2 weighted images of case 2 at baseline pre-transplantation (A,B) and at the last follow-up evaluation (C,D). Panels (A,C) are planes crossing through the basal ganglia, while panels (B,D) are planes crossing through the corona radiata. The baseline study shows the typical changes associated with Krabbe disease at the level of the capsular regions (arrows, A) and periventricular white matter and corona radiata (A,B, arrowheads) in the setting of a still unmyelinated brain. The follow-up evaluation demonstrates a normally myelinated brain, with the exception for the posterior limbs of the internal capsules (arrows, A). The white matter within the corona radiata is now normal appearing, with focal volume loss resulting in atrophy of the bilateral motor strip (arrowheads, D).